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In Vitro Blood–Brain Barrier-Integrated Neurological Disorder Models Using a Microfluidic Device

by Jin-Ha Choi 1,†, Mallesh Santhosh 2,† and Jeong-Woo Choi 1,2,*
1
Department of Chemical and Biomolecular Engineering, Sogang University, 35 Baekbeom-ro (Sinsu-dong), Mapo-gu, 121-742 Seoul, Korea
2
Center for Integrated Biotechnology, Sogang University, 35 Baekbeom-ro (Sinsu-dong), Mapo-gu, 121-742 Seoul, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Micromachines 2020, 11(1), 21; https://doi.org/10.3390/mi11010021
Received: 30 November 2019 / Revised: 20 December 2019 / Accepted: 21 December 2019 / Published: 24 December 2019
(This article belongs to the Special Issue Microfluidic Platforms for Cell Culture and Investigations)
The blood–brain barrier (BBB) plays critical role in the human physiological system such as protection of the central nervous system (CNS) from external materials in the blood vessel, including toxicants and drugs for several neurological disorders, a critical type of human disease. Therefore, suitable in vitro BBB models with fluidic flow to mimic the shear stress and supply of nutrients have been developed. Neurological disorder has also been investigated for developing realistic models that allow advance fundamental and translational research and effective therapeutic strategy design. Here, we discuss introduction of the blood–brain barrier in neurological disorder models by leveraging a recently developed microfluidic system and human organ-on-a-chip system. Such models could provide an effective drug screening platform and facilitate personalized therapy of several neurological diseases. View Full-Text
Keywords: neurological disorders; blood–brain barrier (BBB); microfluidic device; in vitro model; neuroinflammation neurological disorders; blood–brain barrier (BBB); microfluidic device; in vitro model; neuroinflammation
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Choi, J.-H.; Santhosh, M.; Choi, J.-W. In Vitro Blood–Brain Barrier-Integrated Neurological Disorder Models Using a Microfluidic Device. Micromachines 2020, 11, 21.

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