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A Compact, Syringe-Assisted, Vacuum-Driven Micropumping Device

Department of Electrical Engineering, The State University of New York at Buffalo, Buffalo, NY 14260, USA
Department of Biomedical Engineering, The State University of New York at Buffalo, Buffalo, NY 14260, USA
Author to whom correspondence should be addressed.
Micromachines 2019, 10(8), 543;
Received: 5 August 2019 / Revised: 14 August 2019 / Accepted: 14 August 2019 / Published: 17 August 2019
(This article belongs to the Special Issue Biomedical Microfluidic Devices 2019)
In this paper, a simple syringe‑assisted pumping method is introduced. The proposed fluidic micropumping system can be used instead of a conventional pumping system which tends to be large, bulky, and expensive. The micropump was designed separately from the microfluidic channels and directly bonded to the outlet of the microfluidic device. The pump components were composed of a dead‑end channel which was surrounded by a microchamber. A syringe was then connected to the pump structure by a short tube, and the syringe plunger was manually pulled out to generate low pressure inside the microchamber. Once the sample was loaded in the inlet, air inside the channel diffused into the microchamber through the PDMS (polydimethylsiloxane) wall, acting as a dragging force and pulling the sample toward the outlet. A constant flow with a rate that ranged from 0.8 nl · s 1 to 7.5 nl · s 1 was achieved as a function of the geometry of the pump, i.e., the PDMS wall thickness and the diffusion area. As a proof-of-concept, microfluidic mixing was demonstrated without backflow. This method enables pumping for point-of-care testing (POCT) with greater flexibility in hand-held PDMS microfluidic devices. View Full-Text
Keywords: microfluidics; point-of-care; PDMS (polydimethylsiloxane); micropumping microfluidics; point-of-care; PDMS (polydimethylsiloxane); micropumping
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  • Externally hosted supplementary file 1
    Doi: 10.5281/zenodo.3360720
    Description: Equations and figures are available. Video clips are available for; Video S1: pump with no wings. Video S2: pump with 2 wings. Video S3: pump with 4 wings. Video S4: pump with 4 wings. Video S5: micromixing.
MDPI and ACS Style

Wang, A.; Koh, D.; Schneider, P.; Breloff, E.; Oh, K.W. A Compact, Syringe-Assisted, Vacuum-Driven Micropumping Device. Micromachines 2019, 10, 543.

AMA Style

Wang A, Koh D, Schneider P, Breloff E, Oh KW. A Compact, Syringe-Assisted, Vacuum-Driven Micropumping Device. Micromachines. 2019; 10(8):543.

Chicago/Turabian Style

Wang, Anyang, Domin Koh, Philip Schneider, Evan Breloff, and Kwang W. Oh. 2019. "A Compact, Syringe-Assisted, Vacuum-Driven Micropumping Device" Micromachines 10, no. 8: 543.

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