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Open AccessArticle

A Facile Strategy for Visualizing and Modulating Droplet-Based Microfluidics

State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China
School of Information Science and Technology, ShanghaiTech University, Shanghai 201210, China
University of Chinese Academy of Sciences, Beijing 100049, China
Department of Chemistry, College of Science, Shanghai University, Shanghai 200444, China
Authors to whom correspondence should be addressed.
Micromachines 2019, 10(5), 291;
Received: 27 March 2019 / Revised: 22 April 2019 / Accepted: 25 April 2019 / Published: 29 April 2019
In droplet-based microfluidics, visualizing and modulating of droplets is often prerequisite. In this paper, we report a facile strategy for visualizing and modulating high-throughput droplets in microfluidics. In the strategy, by modulating the sampling frequency of a flash light with the droplet frequency, we are able to map a real high frequency signal to a low frequency signal, which facilitates visualizing and feedback controlling. Meanwhile, because of not needing synchronization signals, the strategy can be directly implemented on any droplet-based microfluidic chips. The only cost of the strategy is an additional signal generator. Moreover, the strategy can catch droplets with frequency up to several kilohertz, which covers the range of most high-throughput droplet-based microfluidics. In this paper, the principle, setup and procedure were introduced. Finally, as a demonstration, the strategy was also implemented in a miniaturized picoinjector in order to monitor and control the injection dosage to droplets. We expect that this facile strategy supplies a low-cost yet effective imaging system that can be easily implemented in miniaturized microfluidic systems or general laboratories. View Full-Text
Keywords: microfluidics; droplets; high-throughput; modulate microfluidics; droplets; high-throughput; modulate
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Gao, Z.; Peng, H.; Zhu, M.; Wu, L.; Jia, C.; Zhou, H.; Zhao, J. A Facile Strategy for Visualizing and Modulating Droplet-Based Microfluidics. Micromachines 2019, 10, 291.

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