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Fabrication, Characterization, and Application of Large-Scale Uniformly Hybrid Nanoparticle-Enhanced Raman Spectroscopy Substrates

1
School of Information science and technology, North China University of Technology, No. 5 Jinyuanzhuang Street, Shijingshan District, Beijing 100144, China
2
State Key Laboratory of Advanced Materials for Smart Sensing, General Research Institute for Nonferrous Metals, No. 11 Xingkedong Street, Huairou District, Beijing 101402, China
3
Smart Sensing R&D Center, Institute of Microelectronic of the Chinese Academy of Sciences, No. 3 Western Beitucheng Street, Chaoyang District, Beijing 100029, China
4
Ministry of Agriculture, Chinese Academy of Fishery Sciences, No. 150 Qingta Street, Fengtai District, Beijing 100141, China
5
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
*
Authors to whom correspondence should be addressed.
Micromachines 2019, 10(5), 282; https://doi.org/10.3390/mi10050282
Received: 20 March 2019 / Revised: 18 April 2019 / Accepted: 22 April 2019 / Published: 27 April 2019
(This article belongs to the Special Issue Self-Assembly of Microcomponents)
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PDF [3157 KB, uploaded 27 April 2019]
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Abstract

Surface-enhanced Raman spectroscopy (SERS) substrates with high sensitivity and reproducibility are highly desirable for high precision and even molecular-level detection applications. Here, large-scale uniformly hybrid nanoparticle-enhanced Raman spectroscopy (NERS) substrates with high reproducibility and controllability were developed. Using oxygen plasma treatment, large-area and uniformly rough polystyrene sphere (URPS) arrays in conjunction with 20 nm Au films (AuURPS) were fabricated for SERS substrates. Au nanoparticles and clusters covered the surface of the URPS arrays, and this increased the Raman signal. In the detection of malachite green (MG), the fabricated NERS substrates have high reproducibility and sensitivity. The enhancement factor (EF) of Au nanoparticles and clusters was simulated by finite-difference time-domain (FDTD) simulations and the EF was more than 104. The measured EF of our developed substrate was more than 108 with a relative standard deviation as low as 6.64%–13.84% over 15 points on the substrate. The minimum limit for the MG molecules reached 50 ng/mL. Moreover, the Raman signal had a good linear relationship with the logarithmic concentration of MG, as it ranged from 50 ng/mL to 5 μg/mL. The NERS substrates proposed in this work may serve as a promising detection scheme in chemical and biological fields. View Full-Text
Keywords: SERS; Au nanoparticles; reproducibility; sensitivity; malachite green SERS; Au nanoparticles; reproducibility; sensitivity; malachite green
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Qi, Q.; Liu, C.; Liu, L.; Meng, Q.; Wei, S.; Ming, A.; Zhang, J.; Wang, Y.; Wu, L.; Zhu, X.; Wei, F.; Yan, J. Fabrication, Characterization, and Application of Large-Scale Uniformly Hybrid Nanoparticle-Enhanced Raman Spectroscopy Substrates. Micromachines 2019, 10, 282.

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