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Open AccessPerspective

Engineering Microfluidic Organoid-on-a-Chip Platforms

1
Bio-Manufacturing Programme, Singapore Institute of Manufacturing Technology (SIMTech), Agency for Science, Technology and Research (A*STAR), 2 Fusionopolis Way, #08-04, Innovis, Singapore 138634, Singapore
2
Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive, Proteos, Singapore 138673, Singapore
3
Department of Physiology, 2 Medical Drive, MD9, National University of Singapore, Singapore 117593, Singapore
*
Author to whom correspondence should be addressed.
Micromachines 2019, 10(3), 165; https://doi.org/10.3390/mi10030165
Received: 14 January 2019 / Revised: 21 February 2019 / Accepted: 22 February 2019 / Published: 27 February 2019
(This article belongs to the Special Issue Microfluidic Cell Assay Chips)
In vitro cell culture models are emerging as promising tools to understand human development, disease progression, and provide reliable, rapid and cost-effective results for drug discovery and screening. In recent years, an increasing number of in vitro models with complex organization and controlled microenvironment have been developed to mimic the in vivo organ structure and function. The invention of organoids, self-organized organ-like cell aggregates that originate from multipotent stem cells, has allowed a whole new level of biomimicry to be achieved. Microfluidic organoid-on-a-chip platforms can facilitate better nutrient and gas exchange and recapitulate 3D tissue architecture and physiology. They have the potential to transform the landscape of drug development and testing. In this review, we discuss the challenges in the current organoid models and describe the recent progress in the field of organoid-on-a-chip. View Full-Text
Keywords: organoids; microfluidics; organ-on-a-chip; microbioreactor; drug screening; cell culture organoids; microfluidics; organ-on-a-chip; microbioreactor; drug screening; cell culture
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Yu, F.; Hunziker, W.; Choudhury, D. Engineering Microfluidic Organoid-on-a-Chip Platforms. Micromachines 2019, 10, 165.

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