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Open AccessArticle

Engineering a Bi-Conical Microchip as Vascular Stenosis Model

1
Energy Research Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, China
2
Key Laboratory of Interfacial Reaction & Sensing Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, China
3
Cain Department of Chemical Engineering, Louisiana State University, Baton Rouge, LA 70803, USA
4
Department of Mechanical Engineering, The University of Hong Kong, Hong Kong
*
Authors to whom correspondence should be addressed.
The authors contribute equally to this work.
Micromachines 2019, 10(11), 790; https://doi.org/10.3390/mi10110790
Received: 18 October 2019 / Revised: 10 November 2019 / Accepted: 14 November 2019 / Published: 18 November 2019
(This article belongs to the Special Issue Microengineering Techniques for Disease Modeling and Drug Discovery)
Vascular stenosis is always associated with hemodynamic changes, especially shear stress alterations. Herein, bi-conical shaped microvessels were developed through flexibly and precisely controlled templated methods for hydrogel blood-vessel-like microchip. The blood-vessel-like microvessels demonstrated tunable dimensions, perfusable ability, and good cytocompatibility. The microchips showed blood-vessel-like lumens through fine embeddedness of human umbilical vein endothelial cells (HUVECs) on the interior surface of hydrogel microchannels, which closely reproduced the morphology and functions of human blood vessels. In the gradual narrowing region of bi-conical shape, fluid flow generated wall shear stress, which caused cell morphology variations. Wall shear rates at the gradual narrowing region were simulated by FLUENT software. The results showed that our microchannels qualified for performance as a vascular stenosis-like model in evaluating blood hydrodynamics. In general, our blood-vessel-on-a-chip could offer potential applications in the prevention, diagnosis, and therapy of arterial thrombosis. View Full-Text
Keywords: blood-vessel-like; microchip; bi-conical; vascular stenosis; wall shear rate blood-vessel-like; microchip; bi-conical; vascular stenosis; wall shear rate
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MDPI and ACS Style

Li, Y.; Wang, J.; Wan, W.; Chen, C.; Wang, X.; Zhao, P.; Hou, Y.; Tian, H.; Wang, J.; Nandakumar, K.; Wang, L. Engineering a Bi-Conical Microchip as Vascular Stenosis Model. Micromachines 2019, 10, 790.

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