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Open AccessFeature PaperReview

Chitosans for Tissue Repair and Organ Three-Dimensional (3D) Bioprinting

1
Center of 3D Printing & Organ Manufacturing, School of Fundamental Sciences, China Medical University (CMU), No. 77 Puhe Road, Shenyang North New Area, Shenyang 110122, China
2
Center of Organ Manufacturing, Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China
*
Author to whom correspondence should be addressed.
Micromachines 2019, 10(11), 765; https://doi.org/10.3390/mi10110765
Received: 24 October 2019 / Revised: 4 November 2019 / Accepted: 5 November 2019 / Published: 11 November 2019
(This article belongs to the Special Issue 3D Printing for Tissue Engineering and Regenerative Medicine)
Chitosan is a unique natural resourced polysaccharide derived from chitin with special biocompatibility, biodegradability, and antimicrobial activity. During the past three decades, chitosan has gradually become an excellent candidate for various biomedical applications with prominent characteristics. Chitosan molecules can be chemically modified, adapting to all kinds of cells in the body, and endowed with specific biochemical and physiological functions. In this review, the intrinsic/extrinsic properties of chitosan molecules in skin, bone, cartilage, liver tissue repair, and organ three-dimensional (3D) bioprinting have been outlined. Several successful models for large scale-up vascularized and innervated organ 3D bioprinting have been demonstrated. Challenges and perspectives in future complex organ 3D bioprinting areas have been analyzed. View Full-Text
Keywords: 3D bioprinting; chitosan; chitin; tissue repair; rapid prototyping (RP); implantable bioartificial organs 3D bioprinting; chitosan; chitin; tissue repair; rapid prototyping (RP); implantable bioartificial organs
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Li, S.; Tian, X.; Fan, J.; Tong, H.; Ao, Q.; Wang, X. Chitosans for Tissue Repair and Organ Three-Dimensional (3D) Bioprinting. Micromachines 2019, 10, 765.

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