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Open AccessReview

Engineered Liver-On-A-Chip Platform to Mimic Liver Functions and Its Biomedical Applications: A Review

1
State Key Laboratory of Fine Chemicals, Department of Chemical Engineering, Dalian University of Technology, Dalian 116024, China
2
Integrated Chinese and Western Medicine Postdoctoral research station, Jinan University, Guangzhou 510632, China
3
College of Pharmaceutical Science, Soochow University, Suzhou 215123, China
*
Authors to whom correspondence should be addressed.
These authors have equally contribution to this work.
Micromachines 2019, 10(10), 676; https://doi.org/10.3390/mi10100676
Received: 17 September 2019 / Revised: 3 October 2019 / Accepted: 3 October 2019 / Published: 7 October 2019
(This article belongs to the Special Issue Organs-on-chips)
Hepatology and drug development for liver diseases require in vitro liver models. Typical models include 2D planar primary hepatocytes, hepatocyte spheroids, hepatocyte organoids, and liver-on-a-chip. Liver-on-a-chip has emerged as the mainstream model for drug development because it recapitulates the liver microenvironment and has good assay robustness such as reproducibility. Liver-on-a-chip with human primary cells can potentially correlate clinical testing. Liver-on-a-chip can not only predict drug hepatotoxicity and drug metabolism, but also connect other artificial organs on the chip for a human-on-a-chip, which can reflect the overall effect of a drug. Engineering an effective liver-on-a-chip device requires knowledge of multiple disciplines including chemistry, fluidic mechanics, cell biology, electrics, and optics. This review first introduces the physiological microenvironments in the liver, especially the cell composition and its specialized roles, and then summarizes the strategies to build a liver-on-a-chip via microfluidic technologies and its biomedical applications. In addition, the latest advancements of liver-on-a-chip technologies are discussed, which serve as a basis for further liver-on-a-chip research. View Full-Text
Keywords: liver-on-a-chip; drug hepatotoxicity; drug metabolism liver-on-a-chip; drug hepatotoxicity; drug metabolism
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MDPI and ACS Style

Deng, J.; Wei, W.; Chen, Z.; Lin, B.; Zhao, W.; Luo, Y.; Zhang, X. Engineered Liver-On-A-Chip Platform to Mimic Liver Functions and Its Biomedical Applications: A Review. Micromachines 2019, 10, 676.

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