Next Article in Journal
Tele–Robotic Platform for Dexterous Optical Single-Cell Manipulation
Next Article in Special Issue
A Cancer Spheroid Array Chip for Selecting Effective Drug
Previous Article in Journal
Viscosity Estimation of a Suspension with Rigid Spheres in Circular Microchannels Using Particle Tracking Velocimetry
Previous Article in Special Issue
Liver-on-a-Chip‒Magnetic Nanoparticle Bound Synthetic Metalloporphyrin-Catalyzed Biomimetic Oxidation of a Drug in a Magnechip Reactor
Open AccessReview

Engineered Liver-On-A-Chip Platform to Mimic Liver Functions and Its Biomedical Applications: A Review

State Key Laboratory of Fine Chemicals, Department of Chemical Engineering, Dalian University of Technology, Dalian 116024, China
Integrated Chinese and Western Medicine Postdoctoral research station, Jinan University, Guangzhou 510632, China
College of Pharmaceutical Science, Soochow University, Suzhou 215123, China
Authors to whom correspondence should be addressed.
These authors have equally contribution to this work.
Micromachines 2019, 10(10), 676;
Received: 17 September 2019 / Revised: 3 October 2019 / Accepted: 3 October 2019 / Published: 7 October 2019
(This article belongs to the Special Issue Organs-on-chips)
Hepatology and drug development for liver diseases require in vitro liver models. Typical models include 2D planar primary hepatocytes, hepatocyte spheroids, hepatocyte organoids, and liver-on-a-chip. Liver-on-a-chip has emerged as the mainstream model for drug development because it recapitulates the liver microenvironment and has good assay robustness such as reproducibility. Liver-on-a-chip with human primary cells can potentially correlate clinical testing. Liver-on-a-chip can not only predict drug hepatotoxicity and drug metabolism, but also connect other artificial organs on the chip for a human-on-a-chip, which can reflect the overall effect of a drug. Engineering an effective liver-on-a-chip device requires knowledge of multiple disciplines including chemistry, fluidic mechanics, cell biology, electrics, and optics. This review first introduces the physiological microenvironments in the liver, especially the cell composition and its specialized roles, and then summarizes the strategies to build a liver-on-a-chip via microfluidic technologies and its biomedical applications. In addition, the latest advancements of liver-on-a-chip technologies are discussed, which serve as a basis for further liver-on-a-chip research. View Full-Text
Keywords: liver-on-a-chip; drug hepatotoxicity; drug metabolism liver-on-a-chip; drug hepatotoxicity; drug metabolism
Show Figures

Figure 1

MDPI and ACS Style

Deng, J.; Wei, W.; Chen, Z.; Lin, B.; Zhao, W.; Luo, Y.; Zhang, X. Engineered Liver-On-A-Chip Platform to Mimic Liver Functions and Its Biomedical Applications: A Review. Micromachines 2019, 10, 676.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop