Liver-on-a-Chip‒Magnetic Nanoparticle Bound Synthetic Metalloporphyrin-Catalyzed Biomimetic Oxidation of a Drug in a Magnechip Reactor
by
Balázs Decsi 1,
Réka Krammer 1
,
Kristóf Hegedűs 2,
Ferenc Ender 2,3,
Benjámin Gyarmati 4,
András Szilágyi 4,
Róbert Tőtős 5,
Gabriel Katona 5,
Csaba Paizs 5,
György T. Balogh 6,7,
László Poppe 1,5,8,* and
Diána Balogh-Weiser 1,4,*
Balázs Decsi 1,
Réka Krammer 1,
Kristóf Hegedűs 2,
Ferenc Ender 2,3,
Benjámin Gyarmati 4,
András Szilágyi 4,
Róbert Tőtős 5,
Gabriel Katona 5,
Csaba Paizs 5,
György T. Balogh 6,7,
László Poppe 1,5,8,* and
Diána Balogh-Weiser 1,4,*
1
Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1111 Budapest, Műegyetem rkp. 3, Hungary
2
SpinSplit Llc., 1082 Budapest, Leonardo da Vinci u. 43b, Hungary
3
Department of Electron Devices, Budapest University of Technology and Economics, 1117 Budapest, Magyar tudósok krt. 2, Hungary
4
Department of Physical Chemistry and Materials Science, Budapest University of Technology and Economics, 1111 Budapest, Műegyetem rkp. 3, Hungary
5
Biocatalysis and Biotransformation Research Centre, Faculty of Chemistry and Chemical Engineering, Babeș-Bolyai University of Cluj-Napoca, 400028 Cluj-Napoca, Arany Janos street 11, Romania
6
Department of Chemical and Environmental Process Engineering, Budapest University of Technology and Economics, 1111 Budapest, Budafoki út 8, Hungary
7
Department of Pharmacodynamics and Biopharmacy, University of Szeged, 6720 Szeged, Eötvös u. 6, Hungary
8
SynBiocat Llc., 1172 Budapest, Szilasliget u 3, Hungary
*
Authors to whom correspondence should be addressed.
Micromachines 2019, 10(10), 668; https://doi.org/10.3390/mi10100668
Received: 4 September 2019 / Revised: 26 September 2019 / Accepted: 27 September 2019 / Published: 1 October 2019
(This article belongs to the Special Issue Organs-on-chips)
Biomimetic oxidation of drugs catalyzed by metalloporphyrins can be a novel and promising way for the effective and sustainable synthesis of drug metabolites. The immobilization of 5,10,15,20-tetrakis(2,3,4,5,6-pentafluorophenyl)iron(II) porphyrin (FeTPFP) and 5,10,15,20-tetrakis-(4-sulfonatophenyl)iron(II) porphyrin (FeTSPP) via stable covalent or rapid ionic binding on aminopropyl-functionalized magnetic nanoparticles (MNPs-NH2) were developed. These immobilized catalysts could be efficiently applied for the synthesis of new pharmaceutically active derivatives and liver related phase I oxidative major metabolite of an antiarrhythmic drug, amiodarone integrated in a continuous-flow magnetic chip reactor (Magnechip).
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MDPI and ACS Style
Decsi, B.; Krammer, R.; Hegedűs, K.; Ender, F.; Gyarmati, B.; Szilágyi, A.; Tőtős, R.; Katona, G.; Paizs, C.; Balogh, G.T.; Poppe, L.; Balogh-Weiser, D. Liver-on-a-Chip‒Magnetic Nanoparticle Bound Synthetic Metalloporphyrin-Catalyzed Biomimetic Oxidation of a Drug in a Magnechip Reactor. Micromachines 2019, 10, 668.
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