Liver-on-a-Chip‒Magnetic Nanoparticle Bound Synthetic Metalloporphyrin-Catalyzed Biomimetic Oxidation of a Drug in a Magnechip Reactor

Biocatalysis and Biotransformation Research Centre, Faculty of Chemistry and Chemical Engineering, Babeș-Bolyai University of Cluj-Napoca, 400028 Cluj-Napoca, Arany Janos street 11, Romania

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Department of Chemical and Environmental Process Engineering, Budapest University of Technology and Economics, 1111 Budapest, Budafoki út 8, Hungary

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Department of Pharmacodynamics and Biopharmacy, University of Szeged, 6720 Szeged, Eötvös u. 6, Hungary

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SynBiocat Llc., 1172 Budapest, Szilasliget u 3, Hungary

Authors to whom correspondence should be addressed.

Micromachines 2019, 10(10), 668; https://doi.org/10.3390/mi10100668

Received: 4 September 2019 / Revised: 26 September 2019 / Accepted: 27 September 2019 / Published: 1 October 2019

(This article belongs to the Special Issue Organs-on-chips)

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Abstract

Biomimetic oxidation of drugs catalyzed by metalloporphyrins can be a novel and promising way for the effective and sustainable synthesis of drug metabolites. The immobilization of 5,10,15,20-tetrakis(2,3,4,5,6-pentafluorophenyl)iron(II) porphyrin (FeTPFP) and 5,10,15,20-tetrakis-(4-sulfonatophenyl)iron(II) porphyrin (FeTSPP) via stable covalent or rapid ionic binding on aminopropyl-functionalized magnetic nanoparticles (MNPs-NH₂) were developed. These immobilized catalysts could be efficiently applied for the synthesis of new pharmaceutically active derivatives and liver related phase I oxidative major metabolite of an antiarrhythmic drug, amiodarone integrated in a continuous-flow magnetic chip reactor (Magnechip). View Full-Text

Keywords: drug metabolism; biomimetic oxidation; microfluidics; organ-on-a-chip; liver-on-a-chip

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MDPI and ACS Style

Decsi, B.; Krammer, R.; Hegedűs, K.; Ender, F.; Gyarmati, B.; Szilágyi, A.; Tőtős, R.; Katona, G.; Paizs, C.; Balogh, G.T.; Poppe, L.; Balogh-Weiser, D. Liver-on-a-Chip‒Magnetic Nanoparticle Bound Synthetic Metalloporphyrin-Catalyzed Biomimetic Oxidation of a Drug in a Magnechip Reactor. Micromachines 2019, 10, 668. https://doi.org/10.3390/mi10100668

AMA Style

Decsi B, Krammer R, Hegedűs K, Ender F, Gyarmati B, Szilágyi A, Tőtős R, Katona G, Paizs C, Balogh GT, Poppe L, Balogh-Weiser D. Liver-on-a-Chip‒Magnetic Nanoparticle Bound Synthetic Metalloporphyrin-Catalyzed Biomimetic Oxidation of a Drug in a Magnechip Reactor. Micromachines. 2019; 10(10):668. https://doi.org/10.3390/mi10100668

Chicago/Turabian Style

Decsi, Balázs, Réka Krammer, Kristóf Hegedűs, Ferenc Ender, Benjámin Gyarmati, András Szilágyi, Róbert Tőtős, Gabriel Katona, Csaba Paizs, György T. Balogh, László Poppe, and Diána Balogh-Weiser. 2019. "Liver-on-a-Chip‒Magnetic Nanoparticle Bound Synthetic Metalloporphyrin-Catalyzed Biomimetic Oxidation of a Drug in a Magnechip Reactor" Micromachines 10, no. 10: 668. https://doi.org/10.3390/mi10100668

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Liver-on-a-Chip‒Magnetic Nanoparticle Bound Synthetic Metalloporphyrin-Catalyzed Biomimetic Oxidation of a Drug in a Magnechip Reactor

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