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Open AccessArticle

Liver-on-a-Chip‒Magnetic Nanoparticle Bound Synthetic Metalloporphyrin-Catalyzed Biomimetic Oxidation of a Drug in a Magnechip Reactor

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Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1111 Budapest, Műegyetem rkp. 3, Hungary
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SpinSplit Llc., 1082 Budapest, Leonardo da Vinci u. 43b, Hungary
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Department of Electron Devices, Budapest University of Technology and Economics, 1117 Budapest, Magyar tudósok krt. 2, Hungary
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Department of Physical Chemistry and Materials Science, Budapest University of Technology and Economics, 1111 Budapest, Műegyetem rkp. 3, Hungary
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Biocatalysis and Biotransformation Research Centre, Faculty of Chemistry and Chemical Engineering, Babeș-Bolyai University of Cluj-Napoca, 400028 Cluj-Napoca, Arany Janos street 11, Romania
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Department of Chemical and Environmental Process Engineering, Budapest University of Technology and Economics, 1111 Budapest, Budafoki út 8, Hungary
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Department of Pharmacodynamics and Biopharmacy, University of Szeged, 6720 Szeged, Eötvös u. 6, Hungary
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SynBiocat Llc., 1172 Budapest, Szilasliget u 3, Hungary
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Authors to whom correspondence should be addressed.
Micromachines 2019, 10(10), 668; https://doi.org/10.3390/mi10100668
Received: 4 September 2019 / Revised: 26 September 2019 / Accepted: 27 September 2019 / Published: 1 October 2019
(This article belongs to the Special Issue Organs-on-chips)
Biomimetic oxidation of drugs catalyzed by metalloporphyrins can be a novel and promising way for the effective and sustainable synthesis of drug metabolites. The immobilization of 5,10,15,20-tetrakis(2,3,4,5,6-pentafluorophenyl)iron(II) porphyrin (FeTPFP) and 5,10,15,20-tetrakis-(4-sulfonatophenyl)iron(II) porphyrin (FeTSPP) via stable covalent or rapid ionic binding on aminopropyl-functionalized magnetic nanoparticles (MNPs-NH2) were developed. These immobilized catalysts could be efficiently applied for the synthesis of new pharmaceutically active derivatives and liver related phase I oxidative major metabolite of an antiarrhythmic drug, amiodarone integrated in a continuous-flow magnetic chip reactor (Magnechip). View Full-Text
Keywords: drug metabolism; biomimetic oxidation; microfluidics; organ-on-a-chip; liver-on-a-chip drug metabolism; biomimetic oxidation; microfluidics; organ-on-a-chip; liver-on-a-chip
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Decsi, B.; Krammer, R.; Hegedűs, K.; Ender, F.; Gyarmati, B.; Szilágyi, A.; Tőtős, R.; Katona, G.; Paizs, C.; Balogh, G.T.; Poppe, L.; Balogh-Weiser, D. Liver-on-a-Chip‒Magnetic Nanoparticle Bound Synthetic Metalloporphyrin-Catalyzed Biomimetic Oxidation of a Drug in a Magnechip Reactor. Micromachines 2019, 10, 668.

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