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2D Materials in Development of Electrochemical Point-of-Care Cancer Screening Devices

School of Integrative Engineering, Chung-Ang University, Heukseok-dong, Dongjak-gu, Seoul 06910, Korea
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Author to whom correspondence should be addressed.
These authors contributed equally in this work as the second author.
Micromachines 2019, 10(10), 662; https://doi.org/10.3390/mi10100662
Received: 30 August 2019 / Revised: 28 September 2019 / Accepted: 29 September 2019 / Published: 30 September 2019
(This article belongs to the Special Issue Point-of-Care Devices)
Effective cancer treatment requires early detection and monitoring the development progress in a simple and affordable manner. Point-of care (POC) screening can provide a portable and inexpensive tool for the end-users to conveniently operate test and screen their health conditions without the necessity of special skills. Electrochemical methods hold great potential for clinical analysis of variety of chemicals and substances as well as cancer biomarkers due to their low cost, high sensitivity, multiplex detection ability, and miniaturization aptitude. Advances in two-dimensional (2D) material-based electrochemical biosensors/sensors are accelerating the performance of conventional devices toward more practical approaches. Here, recent trends in the development of 2D material-based electrochemical biosensors/sensors, as the next generation of POC cancer screening tools, are summarized. Three cancer biomarker categories, including proteins, nucleic acids, and some small molecules, will be considered. Various 2D materials will be introduced and their biomedical applications and electrochemical properties will be given. The role of 2D materials in improving the performance of electrochemical sensing mechanisms as well as the pros and cons of current sensors as the prospective devices for POC screening will be emphasized. Finally, the future scopes of implementing 2D materials in electrochemical POC cancer diagnostics for the clinical translation will be discussed. View Full-Text
Keywords: point-of-care; cancer; diagnostics; biosensor; electrochemical; 2D material; graphene; MoS2; Bi2Se3; MXene point-of-care; cancer; diagnostics; biosensor; electrochemical; 2D material; graphene; MoS2; Bi2Se3; MXene
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Mohammadniaei, M.; Nguyen, H.V.; Tieu, M.V.; Lee, M.-H. 2D Materials in Development of Electrochemical Point-of-Care Cancer Screening Devices. Micromachines 2019, 10, 662.

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