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Advancement of Peptide Nanobiotechnology via Emerging Microfluidic Technology

Division of Science, Yale-NUS College, 16 College Avenue West, Singapore 138527, Singapore
Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Singapore
Author to whom correspondence should be addressed.
Micromachines 2019, 10(10), 627;
Received: 20 July 2019 / Revised: 10 September 2019 / Accepted: 18 September 2019 / Published: 20 September 2019
(This article belongs to the Special Issue Nanoparticles on Microfluidic Platforms)
Peptide nanotechnology has experienced a long and enduring development since its inception. Many different applications have been conceptualized, which depends on the functional groups present on the peptide and the physical shape/size of the peptide nanostructures. One of the most prominent nanostructures formed by peptides are nanoparticles. Until recently, however, it has been challenging to engineer peptide nanoparticles with low dispersity. An emerging and promising technique involves the utility of microfluidics to produce a solution of peptide nanoparticles with narrow dispersity. In this process, two or more streams of liquid are focused together to create conditions that are conducive towards the formation of narrowly dispersed samples of peptide nanoparticles. This makes it possible to harness peptide nanoparticles for the myriad of applications that are dependent on nanoparticle size and uniformity. In this focus review, we aim to show how microfluidics may be utilized to (1) study peptide self-assembly, which is critical to controlling nanostructure shape and size, and peptide-interface interactions, and (2) generate self-assembling peptide-based microgels for miniaturized cell cultures. These examples will illustrate how the emerging microfluidic approach promises to revolutionize the production and application of peptide nanoparticles in ever more diverse fields than before. View Full-Text
Keywords: self-assembly; peptides; nanoparticles; low dispersity; microgels; miniaturized cell cultures; microfluidics self-assembly; peptides; nanoparticles; low dispersity; microgels; miniaturized cell cultures; microfluidics
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Chan, K.H.; Tay, J.J.J. Advancement of Peptide Nanobiotechnology via Emerging Microfluidic Technology. Micromachines 2019, 10, 627.

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