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Strategies and Methodologies for Developing Microbial Detoxification Systems to Mitigate Mycotoxins

Guelph Research and Development Centre, Agriculture and Agri-Food Canada, Guelph, ON N1G5C9, Canada
Author to whom correspondence should be addressed.
Academic Editor: Massimo Reverberi
Toxins 2017, 9(4), 130;
Received: 13 February 2017 / Revised: 3 April 2017 / Accepted: 4 April 2017 / Published: 7 April 2017
PDF [611 KB, uploaded 10 April 2017]


Mycotoxins, the secondary metabolites of mycotoxigenic fungi, have been found in almost all agricultural commodities worldwide, causing enormous economic losses in livestock production and severe human health problems. Compared to traditional physical adsorption and chemical reactions, interest in biological detoxification methods that are environmentally sound, safe and highly efficient has seen a significant increase in recent years. However, researchers in this field have been facing tremendous unexpected challenges and are eager to find solutions. This review summarizes and assesses the research strategies and methodologies in each phase of the development of microbiological solutions for mycotoxin mitigation. These include screening of functional microbial consortia from natural samples, isolation and identification of single colonies with biotransformation activity, investigation of the physiological characteristics of isolated strains, identification and assessment of the toxicities of biotransformation products, purification of functional enzymes and the application of mycotoxin decontamination to feed/food production. A full understanding and appropriate application of this tool box should be helpful towards the development of novel microbiological solutions on mycotoxin detoxification. View Full-Text
Keywords: mycotoxin; detoxification; biodegradation; biotransformation; enzyme; microorganism identification mycotoxin; detoxification; biodegradation; biotransformation; enzyme; microorganism identification

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Zhu, Y.; Hassan, Y.I.; Lepp, D.; Shao, S.; Zhou, T. Strategies and Methodologies for Developing Microbial Detoxification Systems to Mitigate Mycotoxins. Toxins 2017, 9, 130.

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