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Article

Evaluation of Inner Exposure of Horses to Zearalenone (ZEN), Deoxynivalenol (DON) and Their Metabolites in Relation to Colic and Health-Related Clinical-Chemical Traits

1
Institute of Animal Nutrition, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Bundesallee 37, 38116 Braunschweig, Germany
2
Institute of Nutritional Physiology “Oskar Kellner”, Leibniz Institute for Farm Animal Biology, Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany
3
Group Animal Nutrition, Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle-Wittenberg, Theodor-Lieser-Str.11, D-06120 Halle/Saale, Germany
4
Clinic for Horses, University of Veterinary Medicine Hannover, Bünteweg 9, 30559 Hannover, Germany
*
Author to whom correspondence should be addressed.
Toxins 2021, 13(8), 588; https://doi.org/10.3390/toxins13080588
Received: 27 June 2021 / Revised: 14 August 2021 / Accepted: 17 August 2021 / Published: 23 August 2021
(This article belongs to the Special Issue Biomonitoring of Mycotoxins)
Mycotoxin contaminated feed has been associated with colic of horses caused by intestinal disorders. Whether such disease conditions alter the intestinal toxin metabolism and transfer across a compromised mucosal barrier is unknown. A screening approach was used to relate blood residue levels of DON, ZEN and their metabolites to the status of the horses (sick vs. healthy). A total of 55 clinically healthy horses from 6 different farms with varying feeding background served as control for sick horses (N = 102) hospitalized due to colic. ZEN, alpha-zearalenol (ZEL), beta-ZEL and DON were detectable in peripheral blood as indicators for the inner exposure with significant farm effects for alpha- and beta-ZEL. However, the levels in sick horses were similar to all farms. Moreover, the proportion of beta-ZEL of all detected ZEN metabolites as an indicator for the degree of metabolism of ZEN was not different for sick horses but differed amongst the control farms. Although the incidence of DON in blood was generally low and not significantly different amongst healthy and sick horses, the positive samples were nearly exclusively found in sick horses suggesting either a higher toxin transfer, an association of DON with the development of colic or a different feeding background. View Full-Text
Keywords: zearalenone; deoxynivalenol; metabolism; horse; health; intestinal disorders; colic zearalenone; deoxynivalenol; metabolism; horse; health; intestinal disorders; colic
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MDPI and ACS Style

Dänicke, S.; Saltzmann, J.; Liermann, W.; Glatter, M.; Hüther, L.; Kersten, S.; Zeyner, A.; Feige, K.; Warnken, T. Evaluation of Inner Exposure of Horses to Zearalenone (ZEN), Deoxynivalenol (DON) and Their Metabolites in Relation to Colic and Health-Related Clinical-Chemical Traits. Toxins 2021, 13, 588. https://doi.org/10.3390/toxins13080588

AMA Style

Dänicke S, Saltzmann J, Liermann W, Glatter M, Hüther L, Kersten S, Zeyner A, Feige K, Warnken T. Evaluation of Inner Exposure of Horses to Zearalenone (ZEN), Deoxynivalenol (DON) and Their Metabolites in Relation to Colic and Health-Related Clinical-Chemical Traits. Toxins. 2021; 13(8):588. https://doi.org/10.3390/toxins13080588

Chicago/Turabian Style

Dänicke, Sven, Janine Saltzmann, Wendy Liermann, Maren Glatter, Liane Hüther, Susanne Kersten, Annette Zeyner, Karsten Feige, and Tobias Warnken. 2021. "Evaluation of Inner Exposure of Horses to Zearalenone (ZEN), Deoxynivalenol (DON) and Their Metabolites in Relation to Colic and Health-Related Clinical-Chemical Traits" Toxins 13, no. 8: 588. https://doi.org/10.3390/toxins13080588

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