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Open AccessArticle

Porcine Hepatic Response to Fumonisin B1 in a Short Exposure Period: Fatty Acid Profile and Clinical Investigations

1
Faculty of Agricultural and Environmental Sciences, Kaposvár University, 7400 Kaposvár, Hungary
2
“MTA-KE Mycotoxins in the Food Chain” Research Group, Hungarian Academy of Sciences, Kaposvár University, 7400 Kaposvár, Hungary
3
Research Institute for Animal Breeding, Nutrition and Meat Science, National Agricultural Research Center, 2053 Herceghalom, Hungary
4
Department of Nutrition, Faculty of Agricultural and Environmental Sciences, Szent István University, 2103 Gödöllő, Hungary
5
Autopsy Ltd., Telepes u. 42, 1147 Budapest, Hungary
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Department of Animal Science, University of Padova, Agripolis, Viale dell’Università 16, 35020 Legnaro, Padova, Italy
*
Author to whom correspondence should be addressed.
Toxins 2019, 11(11), 655; https://doi.org/10.3390/toxins11110655
Received: 2 October 2019 / Revised: 6 November 2019 / Accepted: 8 November 2019 / Published: 10 November 2019
(This article belongs to the Special Issue Mycotoxin Exposure and Related Diseases)
Scarce studies have investigated the impact of fumonisin B1 (FB1) on the hepatic tissue fatty acid (FA) profile, and no study is available on piglets. A 10-day in vivo experiment was performed on seven piglets/group: control and FB1-fed animals (diet was contaminated with fungal culture: 20 mg FB1/kg diet). Independent sample t-test was carried out at p < 0.05 as the significance level. Neither growth, nor feed efficiency, was affected. The hepatic phospholipid (PL) fatty acids (FAs) were more susceptible for FB1, while triglyceride (TG) was less responsive. The impact of FB1 on hepatic PL polyunsaturated fatty acids (PUFAs) was more pronounced than on saturated fatty acids. Among all PUFAs, predominant ones in response were docosapentaenoicacid (DPA) (↓), docosahexaenoic DHA (↓) and arachidonic acids (↑). This led to a higher omega-6:omega-3 ratio, whereas a similar finding was noted in TGs. Neither total saturation (SFA) nor total monousaturation (MUFA) were affected by the FB1 administration. The liver showed an increase in malondialdehyde, as well as antioxidant capacity (reduced glutathione and glutathione peroxidase). The plasma enzymatic assessment revealed an increase in alkaline phosphatase (ALP), while alanine transaminase (ALT), aspartate transaminase (AST), lactate dehydrogenase (LDH), and gamma-glutamyltransferase (GGT) were not influenced. The microscopic sections provided evidence of vacuolar degeneration of the hepatocytes’ cytoplasm, but it was not severe. Furthermore, the lung edema was developed, while the kidney was not affected. In conclusion, regarding FB1-mediated hepatotoxicity in piglets, the potential effect of slight hepatotoxicity did not compromise growth performance, at least at the dose and exposure period applied. View Full-Text
Keywords: fumonisin B1; piglet; liver; lipids; blood serum; oxidation; clinical chemistry; histopathology; phospholipids fumonisin B1; piglet; liver; lipids; blood serum; oxidation; clinical chemistry; histopathology; phospholipids
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Ali, O.; Szabó-Fodor, J.; Fébel, H.; Mézes, M.; Balogh, K.; Glávits, R.; Kovács, M.; Zantomasi, A.; Szabó, A. Porcine Hepatic Response to Fumonisin B1 in a Short Exposure Period: Fatty Acid Profile and Clinical Investigations. Toxins 2019, 11, 655.

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