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Toxins 2018, 10(6), 230; https://doi.org/10.3390/toxins10060230

Fumonisin-Exposure Impairs Age-Related Ecological Succession of Bacterial Species in Weaned Pig Gut Microbiota

1
GenPhySE, Université de Toulouse, INRA, INPT, ENVT, 31326 Castanet-Tolosan, France
2
Lallemand SAS, 19 rue des Briquetiers, BP 59, 31702 Blagnac CEDEX, France
3
Toxalim (Research Center in Food Toxicology), Université de Toulouse, INRA, INP-Purpan, ENVT, UPS, 31027 Toulouse, France
4
PTP Science Park, via Einstein, loc. Cascina Codazza, 26900 Lodi, Italy
*
Authors to whom correspondence should be addressed.
Received: 18 April 2018 / Revised: 25 May 2018 / Accepted: 31 May 2018 / Published: 5 June 2018
(This article belongs to the Special Issue Effects of Mycotoxins on the Intestine)
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Abstract

Pigs are highly affected by dietary mycotoxin contamination and particularly by fumonisin. The effects of fumonisin on pig intestinal health are well documented, but little is known regarding its impact on gut microbiota. We investigate the effects of the fumonisin (FB1, 12 mg/kg feed) on the fecal microbiota of piglets (n = 6) after 0, 8, 15, 22, and 29 days of exposure. A control group of six piglets received a diet free of FB1. Bacterial community diversity, structure and taxonomic composition were carried out by V3–V4 16S rRNA gene sequencing. Exposure to FB1 decreases the diversity index, and shifts and constrains the structure and the composition of the bacterial community. This takes place as early as after 15 days of exposure and is at a maximum after 22 days of exposure. Compared to control, FB1 alters the ecological succession of fecal microbiota species toward higher levels of Lactobacillus and lower levels of the Lachnospiraceae and Veillonellaceae families, and particularly OTUs (Operational Taxonomic Units) of the genera Mitsuokella, Faecalibacterium and Roseburia. In conclusion, FB1 shifts and constrains age-related evolution of microbiota. The direct or indirect contribution of FB1 microbiota alteration in the global host response to FB1 toxicity remains to be investigated. View Full-Text
Keywords: fumonisin; microbiota; pigs; MiSeq 16S rDNA sequencing fumonisin; microbiota; pigs; MiSeq 16S rDNA sequencing
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Mateos, I.; Combes, S.; Pascal, G.; Cauquil, L.; Barilly, C.; Cossalter, A.-M.; Laffitte, J.; Botti, S.; Pinton, P.; Oswald, I.P. Fumonisin-Exposure Impairs Age-Related Ecological Succession of Bacterial Species in Weaned Pig Gut Microbiota. Toxins 2018, 10, 230.

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