Next Article in Journal
Fumonisin-Exposure Impairs Age-Related Ecological Succession of Bacterial Species in Weaned Pig Gut Microbiota
Next Article in Special Issue
Deleting Death and Dialysis: Conservative Care of Cardio-Vascular Risk and Kidney Function Loss in Chronic Kidney Disease (CKD)
Previous Article in Journal
Hydrogen-Rich Water and Lactulose Protect Against Growth Suppression and Oxidative Stress in Female Piglets Fed Fusarium Toxins Contaminated Diets
Previous Article in Special Issue
Uremic Toxin Clearance and Cardiovascular Toxicities
Article Menu
Issue 6 (June) cover image

Export Article

Open AccessFeature PaperReview
Toxins 2018, 10(6), 229; https://doi.org/10.3390/toxins10060229

Uremic Toxins and Clinical Outcomes: The Impact of Kidney Transplantation

1
Division of Clinical Pharmacology and Clinical Research Department, Amiens University Medical Center, 80054 Amiens, France
2
EA 7517, MP3CV laboratory, CURS, Jules Verne University of Picardie, 80054 Amiens, France
3
Division of Nephrology, Ambroise Paré University Medical Center, APHP, Boulogne Billancourt, 92100 Paris, France
4
INSERM U1018, Team 5, CESP (Centre de Recherche en Épidémiologie et Santé des Populations), Paris-Saclay University and Paris Ouest-Versailles-Saint-Quentin-en-Yvelines University (UVSQ), 94800 Villejuif, France
*
Author to whom correspondence should be addressed.
Received: 6 May 2018 / Revised: 31 May 2018 / Accepted: 1 June 2018 / Published: 5 June 2018
(This article belongs to the Special Issue Uremia and Cardiovascular Disease)
Full-Text   |   PDF [288 KB, uploaded 5 June 2018]

Abstract

Non-transplanted and transplanted patients with chronic kidney disease (CKD) differ in terms of mortality and the risk of clinical events. This difference is probably due to the difference of both traditional and non-traditional risk factors. Uremic retention solutes may constitute important non-traditional risk factors in this population. In the present review, we selected a set of uremic toxins that have been associated with harmful effects, and are an appealing target for adjuvant therapy in CKD. For each toxin reviewed here, relevant studies were selected and the relationship with hard clinical outcomes of uremic toxins were compared between non-transplanted CKD patients and transplanted patients taking into account the level of glomerular filtration rate in these two situations. View Full-Text
Keywords: uremic toxins; chronic kidney disease; renal transplantation; outcomes uremic toxins; chronic kidney disease; renal transplantation; outcomes
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Liabeuf, S.; Cheddani, L.; Massy, Z.A. Uremic Toxins and Clinical Outcomes: The Impact of Kidney Transplantation. Toxins 2018, 10, 229.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Toxins EISSN 2072-6651 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top