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Uremic Toxin Clearance and Cardiovascular Toxicities
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Toxins 2018, 10(6), 229;

Uremic Toxins and Clinical Outcomes: The Impact of Kidney Transplantation

Division of Clinical Pharmacology and Clinical Research Department, Amiens University Medical Center, 80054 Amiens, France
EA 7517, MP3CV laboratory, CURS, Jules Verne University of Picardie, 80054 Amiens, France
Division of Nephrology, Ambroise Paré University Medical Center, APHP, Boulogne Billancourt, 92100 Paris, France
INSERM U1018, Team 5, CESP (Centre de Recherche en Épidémiologie et Santé des Populations), Paris-Saclay University and Paris Ouest-Versailles-Saint-Quentin-en-Yvelines University (UVSQ), 94800 Villejuif, France
Author to whom correspondence should be addressed.
Received: 6 May 2018 / Revised: 31 May 2018 / Accepted: 1 June 2018 / Published: 5 June 2018
(This article belongs to the Special Issue Uremia and Cardiovascular Disease)
Full-Text   |   PDF [288 KB, uploaded 5 June 2018]


Non-transplanted and transplanted patients with chronic kidney disease (CKD) differ in terms of mortality and the risk of clinical events. This difference is probably due to the difference of both traditional and non-traditional risk factors. Uremic retention solutes may constitute important non-traditional risk factors in this population. In the present review, we selected a set of uremic toxins that have been associated with harmful effects, and are an appealing target for adjuvant therapy in CKD. For each toxin reviewed here, relevant studies were selected and the relationship with hard clinical outcomes of uremic toxins were compared between non-transplanted CKD patients and transplanted patients taking into account the level of glomerular filtration rate in these two situations. View Full-Text
Keywords: uremic toxins; chronic kidney disease; renal transplantation; outcomes uremic toxins; chronic kidney disease; renal transplantation; outcomes
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Liabeuf, S.; Cheddani, L.; Massy, Z.A. Uremic Toxins and Clinical Outcomes: The Impact of Kidney Transplantation. Toxins 2018, 10, 229.

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