Next Article in Journal
SS1P Immunotoxin Induces Markers of Immunogenic Cell Death and Enhances the Effect of the CTLA-4 Blockade in AE17M Mouse Mesothelioma Tumors
Next Article in Special Issue
Phylogenetic Comparative Methods can Provide Important Insights into the Evolution of Toxic Weaponry
Previous Article in Journal
The Yellow Knight Fights Back: Toxicological, Epidemiological, and Survey Studies Defend Edibility of Tricholoma equestre
Previous Article in Special Issue
Functional Assays for Measuring the Catalytic Activity of Ribosome Inactivating Proteins
Article Menu
Issue 11 (November) cover image

Export Article

Open AccessReview
Toxins 2018, 10(11), 469; https://doi.org/10.3390/toxins10110469

Natural Products to Fight Cancer: A Focus on Juglans regia

1
Department for Life Quality Studies, Alma Mater Studiorum-University of Bologna, corso d’Augusto 237, Rimini 47921, Italy
2
Department of Biomolecular Sciences, University of Urbino Carlo Bo, via Saffi 2, Urbino 61029, Italy
*
Author to whom correspondence should be addressed.
Received: 27 October 2018 / Revised: 7 November 2018 / Accepted: 9 November 2018 / Published: 14 November 2018
(This article belongs to the Special Issue Toxins:10th Anniversary)
Full-Text   |   PDF [1194 KB, uploaded 15 November 2018]   |  

Abstract

Even if cancer represents a burden for human society, an exhaustive cure has not been discovered yet. Low therapeutic index and resistance to pharmacotherapy are two of the major limits of antitumour treatments. Natural products represent an excellent library of bioactive molecules. Thus, tapping into the natural world may prove useful in identifying new therapeutic options with favourable pharmaco-toxicological profiles. Juglans regia, or common walnut, is a very resilient tree that has inhabited our planet for thousands of years. Many studies correlate walnut consumption to beneficial effects towards several chronic diseases, such as cancer, mainly due to the bioactive molecules stored in different parts of the plant. Among others, polyphenols, quinones, proteins, and essential fatty acids contribute to its pharmacologic activity. The present review aims to offer a comprehensive perspective about the antitumour potential of the most promising compounds stored in this plant, such as juglanin, juglone, and the ellagitannin-metabolites urolithins or deriving from walnut dietary intake. All molecules and a chronic intake of the fruit provide tangible anticancer effects. However, the scarcity of studies on humans does not allow results to be conclusive. View Full-Text
Keywords: Juglans regia; walnut; cancer therapy; in vitro studies; in vivo studies; natural products Juglans regia; walnut; cancer therapy; in vitro studies; in vivo studies; natural products
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Catanzaro, E.; Greco, G.; Potenza, L.; Calcabrini, C.; Fimognari, C. Natural Products to Fight Cancer: A Focus on Juglans regia. Toxins 2018, 10, 469.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Toxins EISSN 2072-6651 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top