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Communication

A Proposal for a Study on Treatment Selection and Lifestyle Recommendations in Chronic Inflammatory Diseases: A Danish Multidisciplinary Collaboration on Prognostic Factors and Personalised Medicine

by
Vibeke Andersen
1,2,3,4,*,
Uffe Holmskov
2,
Signe Bek Sørensen
1,
Mohamad Jawhara
1,
Karina W. Andersen
1,
Anette Bygum
5,
Lone Hvid
5,
Jakob Grauslund
6,7,
Jimmi Wied
6,7,
Henning Glerup
8,
Ulrich Fredberg
8,
Jan Alexander Villadsen
8,
Søren Geill Kjær
8,
Jan Fallingborg
9,
Seyed A. G. R. Moghadd
10,
Torben Knudsen
11,
Jacob Brodersen
11,
Jesper Frøjk
11,
Jens F. Dahlerup
12,
Ole Haagen Nielsen
13,
Robin Christensen
14,
Anders Bo Bojesen
1,
Grith Lykke Sorensen
2,
Steffen Thiel
15,
Nils J. Færgeman
16,
Ivan Brandslund
4,17,
Allan Stensballe
18,
Erik Berg Schmidt
19,
Andre Franke
20,
David Ellinghaus
20,
Philip Rosenstiel
20,
Jeroen Raes
21,22,
Berit Heitmann
23,24,
Mette Boye
1,
Charlotte Lindgaard Nielsen
25,
Lars Werner
26,
Jens Kjeldsen
27,† and
Torkell Ellingsen
28,†add Show full author list remove Hide full author list
1
Focused Research Unit for Molecular Diagnostic and Clinical Research, IRS-Center Sonderjylland, Hospital of Southern Jutland, 6200 Aabenraa, Denmark
2
Institute of Molecular Medicine, University of Southern Denmark, 5000 Odense, Denmark
3
OPEN, University of Southern Denmark, 5000 Odense, Denmark
4
Institute of Regional Health Research, University of Southern Denmark, 5000 Odense, Denmark
5
Department of Dermatology and Allergy Centre, Odense University Hospital, 5000 Odense, Denmark
6
Department of Clinical Research, University of Southern Denmark, 5000 Odense, Denmark
7
Department of Ophthalmology, Odense University Hospital, 5000 Odense, Denmark
8
Diagnostic Centre, Silkeborg Regional Hospital, University of Aarhus, 8600 Silkeborg, Denmark
9
Department of Gastroenterology and Hepatology, Aalborg University Hospital, 9100 Aalborg, Denmark
10
Department of Internal Medicine, Regional Hospital Herning, 7400 Herning, Denmark
11
Department of Gastroenterology Hospital of South West Jutland, 6700 Esbjerg, Denmark
12
Department of Hepatology and Gastroenterology, Aarhus University Hospital, 8000 Aarhus, Denmark
13
Department of Gastroenterology D112, Herlev Hospital, University of Copenhagen, 2730 Herlev, Denmark
14
Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital, 2000 Frederiksberg, Denmark
15
Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark
16
Department of Biochemistry and Molecular Biology, Villum Center for Bioanalytical Sciences, University of Southern Denmark, 5000 Odense, Denmark
17
Department of Clinical Biochemistry, Vejle Hospital, 7100 Vejle, Denmark
18
Department of Health Science and Technology, Aalborg University, 9100 Aalborg, Denmark
19
Department of Cardiology, Aalborg University Hospital, 9100 Aalborg, Denmark
20
Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, 24105 Kiel, Germany
21
Department of Microbiology and Immunology, Rega Institute, KU Leuven-University of Leuven, 3000 Leuven, Belgium
22
VIB Center for Microbiology, 3000 Leuven, Belgium
23
Department of Public Health, Section for General Medicine, University of Copenhagen, 1353 Copenhagen, Denmark
24
Research Unit for Dietary Studies, The Parker Institute, Bispebjerg and Frederiksberg Hospital, Part of the Copenhagen University Hospital, 2000 Frederiksberg, Denmark
25
The Danish Colitis-Crohn Association, 5000 Odense, Denmark
26
The Danish Psoriasis Association, 2630 Tåstrup, Denmark
27
Department of Medical Gastroenterology, Odense University Hospital, 5000 Odense, Denmark
28
Department of Rheumatology, Odense University Hospital, 5000 Odense, Denmark
 
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*
Author to whom correspondence should be addressed.
†
Shared last authorship.
Nutrients 2017, 9(5), 499; https://doi.org/10.3390/nu9050499
Received: 2 February 2017 / Revised: 1 May 2017 / Accepted: 7 May 2017 / Published: 15 May 2017
(This article belongs to the Special Issue Nutrition and Diet in IBD)
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Abstract

Chronic inflammatory diseases (CIDs), including Crohn’s disease and ulcerative colitis (inflammatory bowel diseases, IBD), rheumatoid arthritis, psoriasis, psoriatic arthritis, spondyloarthritides, hidradenitis suppurativa, and immune-mediated uveitis, are treated with biologics targeting the pro-inflammatory molecule tumour necrosis factor-α (TNF) (i.e., TNF inhibitors). Approximately one-third of the patients do not respond to the treatment. Genetics and lifestyle may affect the treatment results. The aims of this multidisciplinary collaboration are to identify (1) molecular signatures of prognostic value to help tailor treatment decisions to an individual likely to initiate TNF inhibitor therapy, followed by (2) lifestyle factors that support achievement of optimised treatment outcome. This report describes the establishment of a cohort that aims to obtain this information. Clinical data including lifestyle and treatment response and biological specimens (blood, faeces, urine, and, in IBD patients, intestinal biopsies) are sampled prior to and while on TNF inhibitor therapy. Both hypothesis-driven and data-driven analyses will be performed according to pre-specified protocols including pathway analyses resulting from candidate gene expression analyses and global approaches (e.g., metabolomics, metagenomics, proteomics). The final purpose is to improve the lives of patients suffering from CIDs, by providing tools facilitating treatment selection and dietary recommendations likely to improve the clinical outcome. View Full-Text
Keywords: biomarker; exercise; food; molecular epidemiology; personalized medicine; patient related outcome measures (PROMs); red meat; smoking; treatment outcome; western style diet (WSD) biomarker; exercise; food; molecular epidemiology; personalized medicine; patient related outcome measures (PROMs); red meat; smoking; treatment outcome; western style diet (WSD)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
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MDPI and ACS Style

Andersen, V.; Holmskov, U.; Sørensen, S.B.; Jawhara, M.; Andersen, K.W.; Bygum, A.; Hvid, L.; Grauslund, J.; Wied, J.; Glerup, H.; Fredberg, U.; Villadsen, J.A.; Kjær, S.G.; Fallingborg, J.; Moghadd, S.A.G.R.; Knudsen, T.; Brodersen, J.; Frøjk, J.; Dahlerup, J.F.; Nielsen, O.H.; Christensen, R.; Bojesen, A.B.; Sorensen, G.L.; Thiel, S.; Færgeman, N.J.; Brandslund, I.; Stensballe, A.; Schmidt, E.B.; Franke, A.; Ellinghaus, D.; Rosenstiel, P.; Raes, J.; Heitmann, B.; Boye, M.; Nielsen, C.L.; Werner, L.; Kjeldsen, J.; Ellingsen, T. A Proposal for a Study on Treatment Selection and Lifestyle Recommendations in Chronic Inflammatory Diseases: A Danish Multidisciplinary Collaboration on Prognostic Factors and Personalised Medicine. Nutrients 2017, 9, 499. https://doi.org/10.3390/nu9050499

AMA Style

Andersen V, Holmskov U, Sørensen SB, Jawhara M, Andersen KW, Bygum A, Hvid L, Grauslund J, Wied J, Glerup H, Fredberg U, Villadsen JA, Kjær SG, Fallingborg J, Moghadd SAGR, Knudsen T, Brodersen J, Frøjk J, Dahlerup JF, Nielsen OH, Christensen R, Bojesen AB, Sorensen GL, Thiel S, Færgeman NJ, Brandslund I, Stensballe A, Schmidt EB, Franke A, Ellinghaus D, Rosenstiel P, Raes J, Heitmann B, Boye M, Nielsen CL, Werner L, Kjeldsen J, Ellingsen T. A Proposal for a Study on Treatment Selection and Lifestyle Recommendations in Chronic Inflammatory Diseases: A Danish Multidisciplinary Collaboration on Prognostic Factors and Personalised Medicine. Nutrients. 2017; 9(5):499. https://doi.org/10.3390/nu9050499

Chicago/Turabian Style

Andersen, Vibeke, Uffe Holmskov, Signe B. Sørensen, Mohamad Jawhara, Karina W. Andersen, Anette Bygum, Lone Hvid, Jakob Grauslund, Jimmi Wied, Henning Glerup, Ulrich Fredberg, Jan A. Villadsen, Søren G. Kjær, Jan Fallingborg, Seyed A.G.R. Moghadd, Torben Knudsen, Jacob Brodersen, Jesper Frøjk, Jens F. Dahlerup, Ole H. Nielsen, Robin Christensen, Anders B. Bojesen, Grith L. Sorensen, Steffen Thiel, Nils J. Færgeman, Ivan Brandslund, Allan Stensballe, Erik B. Schmidt, Andre Franke, David Ellinghaus, Philip Rosenstiel, Jeroen Raes, Berit Heitmann, Mette Boye, Charlotte L. Nielsen, Lars Werner, Jens Kjeldsen, and Torkell Ellingsen. 2017. "A Proposal for a Study on Treatment Selection and Lifestyle Recommendations in Chronic Inflammatory Diseases: A Danish Multidisciplinary Collaboration on Prognostic Factors and Personalised Medicine" Nutrients 9, no. 5: 499. https://doi.org/10.3390/nu9050499

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