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Open AccessReview

The Impact of Exclusive Enteral Nutrition (EEN) on the Gut Microbiome in Crohn’s Disease: A Review

1
Division of Pediatric Gastroenterology and Nutrition, IWK Health Centre, Halifax, NS B3K 6R8, Canada
2
Department of Medicine, Dalhousie University, Halifax, NS B3H 2Y9, Canada
3
Department of Applied Human Nutrition, Mount Saint Vincent University, Halifax, NS B3M 2J6, Canada
4
Department of Pharmacology, Dalhousie University, Halifax, NS B3H 4R2, Canada
5
Division of Pediatric Gastroenterology and Nutrition, Department of Pediatrics, Dalhousie University, Halifax, NS B3K 6R8, Canada
6
Department of Immunology & Microbiology, Dalhousie University, Halifax, NS B3K 6R8, Canada
*
Author to whom correspondence should be addressed.
To be considered joint first authors.
Nutrients 2017, 9(5), 447; https://doi.org/10.3390/nu9050447
Received: 21 March 2017 / Revised: 18 April 2017 / Accepted: 26 April 2017 / Published: 1 May 2017
(This article belongs to the Special Issue Nutrition and Diet in IBD)
Crohn’s disease (CD), a form of inflammatory bowel disease (IBD), is thought to arise from a complex interaction of genetics, the gut microbiome, and environmental factors, such as diet. There is clear evidence that dietary intervention is successful in the treatment of CD—exclusive enteral nutrition (EEN) is able to induce remission in up to 80% of CD patients. While the mechanism of action of EEN is not clear, EEN is known to cause profound changes in the gut microbiome. Understanding how EEN modifies the gut microbiome to induce remission could provide insight into CD etiopathogenesis and aid the development of microbiome-targeted interventions to guide ongoing dietary therapy to sustain remission. This review includes current literature on changes in composition and function of the gut microbiome associated with EEN treatment in CD patients. View Full-Text
Keywords: exclusive enteral nutrition; Crohn’s disease; microbiome exclusive enteral nutrition; Crohn’s disease; microbiome
MDPI and ACS Style

MacLellan, A.; Connors, J.; Grant, S.; Cahill, L.; Langille, M.G.I.; Van Limbergen, J. The Impact of Exclusive Enteral Nutrition (EEN) on the Gut Microbiome in Crohn’s Disease: A Review. Nutrients 2017, 9, 447.

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