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Open AccessArticle

Normal Bone Mineral Density Associates with Duodenal Mucosa Healing in Adult Patients with Celiac Disease on a Gluten-Free Diet

Department of Health Sciences, University of Catanzaro “Magna Graecia”, Viale Europa, Germaneto, Catanzaro 88100, Italy
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Nutrients 2017, 9(2), 98; https://doi.org/10.3390/nu9020098
Received: 11 January 2017 / Accepted: 23 January 2017 / Published: 31 January 2017
Impairment of bone mineral density (BMD) is frequent in celiac disease (CD) patients on a gluten-free diet (GFD). The normalization of intestinal mucosa is still difficult to predict. We aim to investigate the relationship between BMD and duodenal mucosa healing (DMH) in CD patients on a GFD. Sixty-four consecutive CD patients on a GFD were recruited. After a median period of a 6-year GFD (range 2–33 years), patients underwent repeat duodenal biopsy and dual-energy X-ray absorptiometry (DXA) scan. Twenty-four patients (38%) displayed normal and 40 (62%) low BMD, 47 (73%) DMH, and 17 (27%) duodenal mucosa lesions. All patients but one with normal BMD (23 of 24, 96%) showed DMH, while, among those with low BMD, 24 (60%) did and 16 (40%) did not. At multivariate analysis, being older (odds ratio (OR) 1.1, 95% confidence interval (CI) 1.03–1.18) and having diagnosis at an older age (OR 1.09, 95% CI 1.03–1.16) were associated with low BMD; in turn, having normal BMD was the only variable independently associated with DMH (OR 17.5, 95% CI 1.6–192). In older CD patients and with late onset disease, BMD recovery is not guaranteed, despite a GFD. A normal DXA scan identified CD patients with DMH; thus, it is a potential tool in planning endoscopic resampling. View Full-Text
Keywords: celiac disease; bone disorders; osteoporosis; histopathology; intestinal mucosa healing celiac disease; bone disorders; osteoporosis; histopathology; intestinal mucosa healing
MDPI and ACS Style

Larussa, T.; Suraci, E.; Imeneo, M.; Marasco, R.; Luzza, F. Normal Bone Mineral Density Associates with Duodenal Mucosa Healing in Adult Patients with Celiac Disease on a Gluten-Free Diet. Nutrients 2017, 9, 98.

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