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Nutrients 2017, 9(1), 30;

Effect of Two Different Multimicronutrient Supplements on Vitamin D Status in Women of Childbearing Age: A Randomized Trial

Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria
Institute of Food Science and Human Nutrition, Leibniz University of Hannover, Am Kleinen Felde 30, 30167 Hannover, Germany
BioTeSys GmbH, Schelztorstrasse 54-56, 73728 Esslingen, Germany
Department of Mathematics, Natural and Economic Sciences, University of Applied Science Ulm, Albert-Einstein-Allee 55, 89081 Ulm, Germany
Aarhus Institute of Advanced Studies, University of Aarhus, Hoegh-Guldbergs Gade 6B, Building 1632, DK-8000 Aarhus, Denmark
Author to whom correspondence should be addressed.
Received: 18 November 2016 / Revised: 12 December 2016 / Accepted: 23 December 2016 / Published: 4 January 2017
(This article belongs to the Special Issue Vitamin D: Current Issues and New Perspectives)
PDF [1869 KB, uploaded 4 January 2017]


The German Nutrition Society raised in 2012 the recommended daily vitamin D intake from 200 to 800 international units (IU) to achieve 25-hydroxyvitamin D (25(OH)D) levels of at least 50 nmol/L, even when endogenous vitamin D synthesis is minimal such as in winter. We aimed to evaluate this recommendation in women of childbearing age. This is a single-center, randomized, open trial conducted from 8 January to 9 May 2016 in Esslingen, Germany. We randomized 201 apparently healthy women to receive for 8 weeks a daily multimicronutrient supplement containing either 200 IU (n = 100) or 800 IU vitamin D3 (n = 101). Primary outcome measure was serum 25(OH)D. 196 participants completed the trial. Increases in 25(OH)D (median with interquartile range) from baseline to study end were 13.2 (5.9 to 20.7) nmol/L in the 200 IU group, and 35.8 (18.2 to 52.8) nmol/L in the 800 IU group (p < 0.001 for the between group difference). At study end, levels of ≥50 nmol/L were present in 70.4% of the 200 IU group and in 99% of the 800 IU group. Participants on hormonal contraceptives had higher baseline levels and a stronger increase in 25(OH)D. In conclusion, daily supplementation of 800 IU vitamin D3 during wintertime in Germany is sufficient to achieve a 25(OH)D level of at least 50 nmol/L in almost all women of childbearing age, whereas 200 IU are insufficient. View Full-Text
Keywords: randomized controlled trial; vitamin D; supplementation; multimicronutrient; women; 25(OH)D randomized controlled trial; vitamin D; supplementation; multimicronutrient; women; 25(OH)D

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Pilz, S.; Hahn, A.; Schön, C.; Wilhelm, M.; Obeid, R. Effect of Two Different Multimicronutrient Supplements on Vitamin D Status in Women of Childbearing Age: A Randomized Trial. Nutrients 2017, 9, 30.

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