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Open AccessArticle

25-Hydroxy-Vitamin D Concentration Is Not Affected by Severe or Non-Severe Pneumonia, or Inflammation, in Young Children

Innlandet Hospital Trust, Lillehammer, Anders Sandvigs gt. 17, 2609 Lillehammer, Norway
Centre for Intervention Science in Maternal and Child Health, Centre for International Health, University of Bergen, Årstav. 21, 5009 Bergen, Norway
Department of Community Medicine, Kathmandu Medical College, P.O. Box 21266, Sinamangal, 44600 Kathmandu, Nepal
Department of Child Health, Institute of Medicine, Tribhuvan University, Maharajgunj, P.O. Box 1524, 44600 Kathmandu, Nepal
University Hospital of Northern Norway, Sykehusv. 38, 9019 Tromsø, Norway
Broegelmann Research Laboratory, Dept. of Clinical Sciences, University of Bergen, Jonas Lies v. 87, 5021 Bergen, Norway
Department of Infectious Disease Epidemiology, Statens Serum Institut, Artilleriv 5, 2300 Copenhagen S, Denmark
Author to whom correspondence should be addressed.
Nutrients 2017, 9(1), 52;
Received: 2 November 2016 / Revised: 3 December 2016 / Accepted: 4 January 2017 / Published: 17 January 2017
(This article belongs to the Special Issue Vitamin D: Current Issues and New Perspectives)
Poor vitamin D status has been associated with increased risk and severity of respiratory tract infections. Whether or not inflammation and infection affects 25-hydroxy vitamin D (25(OH)D) concentration is controversial and is important in the interpretation of observational studies using plasma-25(OH)D as a biomarker for status. Our objectives were to measure whether 25(OH)D concentration was altered by an episode of acute lower respiratory tract infection and whether markers of inflammation predicted the 25(OH)D concentration. Children aged 2–35 months with severe (n = 43) and non-severe (n = 387) community-acquired, WHO-defined pneumonia were included. 25(OH)D concentration and inflammatory markers (cytokines, chemokines, and growth factors) were measured in plasma during the acute phase and 14, 45, and 90 days later. Predictors for 25(OH)D concentrations were identified in multiple linear regression models. Mean 25(OH)D concentration during the acute phase and after recovery (14, 45, and 90 days) was 84.4 nmol/L ± 33.6, and 80.6 ± 35.4, respectively. None of the inflammatory markers predicted 25(OH)D concentration in the multiple regression models. Age was the most important predictor for 25(OH)D concentration, and there were no differences in 25(OH)D concentrations during illness and after 14, 45, and 90 days when adjusting for age. Infection and inflammation did not alter the 25(OH)D concentration in young children with acute lower respiratory tract infections. View Full-Text
Keywords: acute lower respiratory tract infection; children; inflammation; vitamin D; Nepal acute lower respiratory tract infection; children; inflammation; vitamin D; Nepal
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Haugen, J.; Chandyo, R.K.; Ulak, M.; Mathisen, M.; Basnet, S.; Brokstad, K.A.; Valentiner-Branth, P.; Shrestha, P.S.; Strand, T.A. 25-Hydroxy-Vitamin D Concentration Is Not Affected by Severe or Non-Severe Pneumonia, or Inflammation, in Young Children. Nutrients 2017, 9, 52.

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