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Open AccessReview

Bioactive Compounds and Their Neuroprotective Effects in Diabetic Complications

by 1,2
Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 406-723, Korea
Gachon Medical Research Institute, Gil Hospital, Incheon 406-723, Korea
Nutrients 2016, 8(8), 472;
Received: 23 June 2016 / Revised: 22 July 2016 / Accepted: 27 July 2016 / Published: 30 July 2016
Hyperglycemia, hyperlipidemia and impaired insulin signaling during the development of diabetes can cause diabetic complications, such as diabetic neuropathy, resulting in significant morbidity and mortality. Although various therapeutics are available for the treatment of diabetic neuropathy, no absolute cure exists, and additional research is necessary to comprehensively understand the underlying pathophysiological pathways. A number of studies have demonstrated the potential health benefits of bioactive compounds, i.e., flavonoids and vitamins, which may be effective as supplementary treatments for diabetes and its complications. In this review, we highlight the most recent reports about the mechanisms of action of bioactive compounds (flavonoids and vitamins) possessing potential neuroprotective properties in diabetic conditions. Additional clinical studies are required to determine the appropriate dose and duration of bioactive compound supplementation for neuroprotection in diabetic patients. View Full-Text
Keywords: flavonoids; vitamins; diabetes; neuroprotection flavonoids; vitamins; diabetes; neuroprotection
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Oh, Y.S. Bioactive Compounds and Their Neuroprotective Effects in Diabetic Complications. Nutrients 2016, 8, 472.

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