The Association of Vitamin D Status with Dyslipidaemia and Biomarkers of Endothelial Cell Activation in Older Australians
Abstract
:1. Introduction
2. Experimental Section
2.1. Subject Selection
2.2. Blood Analysis
2.3. Statistical Analysis
3. Results
3.1. 25(OH)D and Lipids Profiles
3.2. Systemic Inflammatory Biomarkers and Endothelial Cells Activation Molecules
4. Discussion
5. Limitations
6. Conclusions & Future Directions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Variable | Tertile 1 (N = 25) | Tertile 2 (N = 29) | Tertile 3 (N = 29) | p Value |
---|---|---|---|---|
25(OH)D (nmol/L) | 97.00 (83.00–202.60) | 74.50 (66.00–83.00) | 56.8 (26.34–65.42) | |
Age (years) | 65.85 (1.44) | 65.12 (1.44) | 64.96 (1.44) | 0.720 |
Gender (M/F) | 13 (39.4)/20(60.6) | 11 (33.3)/22 (66.7) | 20 (57.1)/15 (42.9) | 0.119 |
Weight (kg) | 81.38 (2.60) | 78.27 (2.42) | 76.34 (2.42) | 0.945 |
BMI (kg/m2) | 28.18 (0.91) | 28.45 (0.84) | 27.62 (0.84) | 0.609 |
SBP (mmHg) | 148.12 (4.26) | 143.00 (3.95) | 142.69 (3.95) | 0.734 |
DBP (mmHg) | 84.52 (2.07) | 80.14 (1.93) | 81.41 (1.93) | 0.387 |
PTH (pmol/L) | 7.7 (13.88) | 4.7 (2.74) | 6.2 (4.81) | 0.421 |
McAuley’s index | 8.3 (2.21) | 8.3 (2.26) | 8.3 (2.17) | 0.999 |
Marker | Tertile 1 (N = 25) | Tertile 2 (N = 29) | Tertile 3 (N = 29) |
---|---|---|---|
25(OH)D (nmol/L) | 97.0 (83.00–202.6) | 74.5 (66.00–83.0) | 56.8 (26.34–65.42) |
TC (mmol/L) | 4.87 ** (4.18–5.83) | 4.91 † (3.92–5.85) | 5.91 (4.52–6.48) |
LDL-C (mmol/L) | 2.80 ** (2.31–3.69) | 2.79 † (2.16–3.55) | 3.64 (2.60–4.09) |
TAG (mmol/L) 1 | 1.16 (0.46–2.60) | 1.13 * (0.40–2.57) | 1.37 (0.52 –2.50) |
HDL-C (mmol/L) | 1.30 (0.98–1.86) | 1.43 (1.05–1.82) | 1.45 (1.09–1.86) |
Marker | Tertile 1 (N = 25) | Tertile 2 (N = 29) | Tertile 3 (N = 29) |
---|---|---|---|
25(OH)D (nmol/L) | 97.0 (83.0–202.6) | 74.5 (66.0–83.0) | 56.8 (26.3–65.4) |
TNF–α (pg/mL) | 5.40 (3.80–9.12) | 4.40 (3.10–6.00) | 4.10 (3.10–6.46) |
CRP (ng/L) | 2134.50 (933.00–9120.00) | 2079.00 (891.00–4467.00) | 2359.00 (1122.0–9550.0) |
Leptin (pg/mL) | 7952 (4074–79433) | 11871.4 (3020–40738) | 8323.40 (2692–51286) |
D–dimer (pg/mL) | 2538 (1318–3162) | 2258 (1513–3548) | 1958 (1122–3630) |
sICAM-1 (pg/mL) | 126.00 (109.6–144.5) | 114.40 (95.5–141) | 132.77 (117.5–158.5) |
MPO (pg/mL) | 358.00 (302.00–447.00) | 309.00 (219.00–417.00) | 399.00 (288.40–489.80) |
P-selectin (pg/mL) | 130.00 (115.00–186.00) | 141.00 (100.00–199.50) | 159.00 (104.70–195.00) |
sVCAM-1 (pg/mL) 1 | 877.00 * (708.0–955.00) | 705.80 (616.50–832.00) | 703.00 (602.60–891.30) |
HGF (pg/mL) | 512.50 ** (355.00–633.50) | 351.60 (263.00–509.00) | 318.50 (219.00–426.80) |
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Alyami, A.M.; Lam, V.; Soares, M.J.; Zhao, Y.; Sherriff, J.L.; Mamo, J.C.; James, A.P.; Coombes, F. The Association of Vitamin D Status with Dyslipidaemia and Biomarkers of Endothelial Cell Activation in Older Australians. Nutrients 2016, 8, 457. https://doi.org/10.3390/nu8080457
Alyami AM, Lam V, Soares MJ, Zhao Y, Sherriff JL, Mamo JC, James AP, Coombes F. The Association of Vitamin D Status with Dyslipidaemia and Biomarkers of Endothelial Cell Activation in Older Australians. Nutrients. 2016; 8(8):457. https://doi.org/10.3390/nu8080457
Chicago/Turabian StyleAlyami, Ali M., Virginie Lam, Mario J. Soares, Yun Zhao, Jillian L. Sherriff, John C. Mamo, Anthony P. James, and Fiona Coombes. 2016. "The Association of Vitamin D Status with Dyslipidaemia and Biomarkers of Endothelial Cell Activation in Older Australians" Nutrients 8, no. 8: 457. https://doi.org/10.3390/nu8080457