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Open AccessFeature PaperReview

Dietary Interventions and Changes in Cardio-Metabolic Parameters in Metabolically Healthy Obese Subjects: A Systematic Review with Meta-Analysis

Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114-116, Nuthetal 14558, Germany
Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Szpitalna Str 27/33, Poznan 60-572, Poland
Author to whom correspondence should be addressed.
Nutrients 2016, 8(8), 455;
Received: 8 May 2016 / Revised: 14 July 2016 / Accepted: 25 July 2016 / Published: 28 July 2016
(This article belongs to the Special Issue Metabolically Healthy Obesity)
The aim of this systematic review was to assess the effect of diet on changes in parameters describing the body size phenotype of metabolically healthy obese subjects. The databases Medline, Scopus, Web of Knowledge and Embase were searched for clinical studies carried out between 1958 and June 2016 that reported the effect of dietary intervention on BMI, blood pressure, concentration of fasting triglyceride (TG), high density lipoprotein cholesterol (HDL-C), fasting glucose level, the homoeostatic model assessment of insulin resistance (HOMA-IR) and high sensitivity C-Reactive Protein (hsCRP) in metabolically healthy, obese subjects. Twelve clinical studies met inclusion criteria. The combined analyzed population consists of 1827 subjects aged 34.4 to 61.1 with a BMI > 30 kg/m2. Time of intervention ranged from eight to 104 weeks. The baseline characteristics related to lipid profile were more favorable for metabolically healthy obese than for metabolically unhealthy obese. The meta-analyses revealed a significant associations between restricted energy diet and BMI (95% confidence interval (CI): −0.88, −0.19), blood pressure (systolic blood pressure (SBP): −4.73 mmHg; 95% CI: −7.12, −2.33; and diastolic blood pressure (DBP): −2.75 mmHg; 95% CI: −4.30, −1.21) and TG (−0.11 mmol/l; 95% CI: −0.16, −0.06). Changes in fasting glucose, HOMA-IR and hsCRP did not show significant changes. Sufficient evidence was not found to support the use of specific diets in metabolically healthy obese subjects. This analysis suggests that the effect of caloric restriction exerts its effects through a reduction in BMI, blood pressure and triglycerides in metabolically healthy obese (MHO) patients. View Full-Text
Keywords: metabolically healthy obese; diet; biomarkers metabolically healthy obese; diet; biomarkers
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MDPI and ACS Style

Stelmach-Mardas, M.; Walkowiak, J. Dietary Interventions and Changes in Cardio-Metabolic Parameters in Metabolically Healthy Obese Subjects: A Systematic Review with Meta-Analysis. Nutrients 2016, 8, 455.

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