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Open AccessArticle

Mother and Infant Body Mass Index, Breast Milk Leptin and Their Serum Leptin Values

1
Department of Pediatrics, Regina Margherita Children’ Hospital, Città della Salute e della Scienza di Torino, Piazza Polonia 94, Torino I-10126, Italy
2
Department of Public Health and Pediatric Sciences, University of Turin I-10126, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2016, 8(6), 383; https://doi.org/10.3390/nu8060383
Received: 17 May 2016 / Revised: 15 June 2016 / Accepted: 17 June 2016 / Published: 21 June 2016
(This article belongs to the Special Issue Metabolically Healthy Obesity)
Purpose: This study investigates correlations between mother and infant Body Mass Index (BMI), their serum leptin values and breast milk leptin concentration in early infancy. Subjects and Methods: We determined serum leptin values in 58 healthy infants and leptin values in their mothers’ breast milk, using radioimmunoassay (RIA). Infant and maternal anthropometrics were measured. Results: Median leptin concentration was 3.9 ng/mL (interquartile range (IQR): 2.75) in infant serum, 4.27 ng/mL (IQR: 5.62) in maternal serum and 0.89 ng/mL (IQR: 1.32) in breast milk. Median maternal BMI and weight were 24 kg/m2 (IQR: 4.41) and 64 kg (IQR: 15). Median infant BMI was 15.80 kg/cm2 (IQR: 4.02), while average weight was 5.130 kg (IQR: 1.627). Infants serum leptin values positively correlated with infants’ BMI (p = 0.001; r = 0.213) and breast milk leptin (p = 0.03; r = 0.285). Maternal serum leptin values positively correlated with maternal BMI (p = 0.000, r = 0.449) and breast milk leptin ones (p = 0.026; r = 0.322). Conclusion: Breast milk leptin and maternal BMI could influence infant serum leptin values. Further studies are needed to better elucidate the role of genetics and environment on infant leptin production and risk of obesity later in life. View Full-Text
Keywords: mothers; serum leptin; BMI; breast milk; infancy mothers; serum leptin; BMI; breast milk; infancy
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Savino, F.; Sardo, A.; Rossi, L.; Benetti, S.; Savino, A.; Silvestro, L. Mother and Infant Body Mass Index, Breast Milk Leptin and Their Serum Leptin Values. Nutrients 2016, 8, 383.

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