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Open AccessArticle

Maternal Vitamin D Status and Adverse Birth Outcomes in Children from Rural Western Kenya

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School of Biological and Physical Sciences, Maseno University, Kisumu, Kenya
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Center for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya
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Jomo Kenyatta University of Agriculture and Technology, Nairobi, Kenya
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Division of Nutritional Sciences, Cornell University, 314 Savage Hall, Ithaca, NY 14853, USA
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African Institute for Development Policy, Nairobi, Kenya
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Case Western Reserve University, Cleveland, OH 44106, USA
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SUNY Upstate Medical University, Syracuse, NY 13210, USA
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Department of Immunology and Microbiology, University of Colorado, Denver, Aurora, CO 80045, USA
*
Authors to whom correspondence should be addressed.
Nutrients 2016, 8(12), 794; https://doi.org/10.3390/nu8120794
Received: 9 July 2016 / Revised: 7 November 2016 / Accepted: 24 November 2016 / Published: 7 December 2016
(This article belongs to the Special Issue Vitamin D: Current Issues and New Perspectives)
Maternal plasma 25-hydroxyvitamin D (25(OH)D) status and its association with pregnancy outcomes in malaria holoendemic regions of sub-Saharan Africa is poorly defined. We examined this association and any potential interaction with malaria and helminth infections in an ongoing pregnancy cohort study in Kenya. The association of maternal plasma 25(OH)D status with pregnancy outcomes and infant anthropometric measurements at birth was determined in a subset of women (n = 63). Binomial and linear regression analyses were used to examine associations between maternal plasma 25(OH)D and adverse pregnancy outcomes. Fifty-one percent of the women had insufficient (<75 nmol/L) and 21% had deficient (<50 nmol/L) plasma 25(OH)D concentration at enrollment. At birth, 74.4% of the infants had insufficient and 30% had deficient plasma 25(OH)D concentrations, measured in cord blood. Multivariate analysis controlling for maternal age and body mass index (BMI) at enrollment and gestational age at delivery found that deficient plasma 25(OH)D levels were associated with a four-fold higher risk of stunting in neonates (p = 0.04). These findings add to the existing literature about vitamin D and its association with linear growth in resource-limited settings, though randomized clinical trials are needed to establish causation. View Full-Text
Keywords: maternal vitamin D status; pregnancy outcomes; stunting; Africa; malaria and helminth infections maternal vitamin D status; pregnancy outcomes; stunting; Africa; malaria and helminth infections
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Toko, E.N.; Sumba, O.P.; Daud, I.I.; Ogolla, S.; Majiwa, M.; Krisher, J.T.; Ouma, C.; Dent, A.E.; Rochford, R.; Mehta, S. Maternal Vitamin D Status and Adverse Birth Outcomes in Children from Rural Western Kenya. Nutrients 2016, 8, 794.

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