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Per-Arnt-Sim Kinase (PASK): An Emerging Regulator of Mammalian Glucose and Lipid Metabolism

Department of Clinical Pharmacy, Shanghai General Hospital, School of medicine, Shanghai Jiaotong University, No.100 Haining Road, Shanghai 200025, China
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These authors contributed equally to this paper.
Nutrients 2015, 7(9), 7437-7450; https://doi.org/10.3390/nu7095347
Received: 16 May 2015 / Revised: 27 August 2015 / Accepted: 31 August 2015 / Published: 7 September 2015
Per-Arnt-Sim Kinase (PASK) is an evolutionarily-conserved nutrient-responsive protein kinase that regulates lipid and glucose metabolism, mitochondrial respiration, phosphorylation, and gene expression. Recent data suggests that mammalian PAS kinase is involved in glucose metabolism and acts on pancreatic islet α/β cells and glycogen synthase (GS), affecting insulin secretion and blood glucose levels. In addition, PASK knockout mice (PASK-/-) are protected from obesity, liver triglyceride accumulation, and insulin resistance when fed a high-fat diet, implying that PASK may be a new target for metabolic syndrome (MetS) treatment as well as the cellular nutrients and energy sensors—adenosine monophosphate (AMP)-activated protein kinase (AMPK) and the targets of rapamycin (m-TOR). In this review, we will briefly summarize the regulation of PASK on mammalian glucose and lipid metabolism and its possible mechanism, and further explore the potential targets for MetS therapy. View Full-Text
Keywords: Per-Arnt-Sim kinase (PASK); metabolic syndrome (MetS); glucose and lipid metabolism; protein regulation Per-Arnt-Sim kinase (PASK); metabolic syndrome (MetS); glucose and lipid metabolism; protein regulation
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Zhang, D.-D.; Zhang, J.-G.; Wang, Y.-Z.; Liu, Y.; Liu, G.-L.; Li, X.-Y. Per-Arnt-Sim Kinase (PASK): An Emerging Regulator of Mammalian Glucose and Lipid Metabolism. Nutrients 2015, 7, 7437-7450.

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