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Open AccessReview

B-Vitamins and Bone Health–A Review of the Current Evidence

by Zhaoli Dai 1,* and Woon-Puay Koh 2,*
1
Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Block MD1, 12 Science Drive 2, Singapore 117549, Singapore
2
Office of Clinical Sciences, Duke-NUS Graduate Medical School Singapore, Singapore, 8 College Road Level 4, Singapore 169857, Singapore
*
Authors to whom correspondence should be addressed.
Nutrients 2015, 7(5), 3322-3346; https://doi.org/10.3390/nu7053322
Received: 14 January 2015 / Revised: 24 April 2015 / Accepted: 27 April 2015 / Published: 7 May 2015
(This article belongs to the Special Issue Nutrition and Bone Health)
Because of ongoing global ageing, there is a rapid worldwide increase in incidence of osteoporotic fractures and the resultant morbidity and mortality associated with these fractures are expected to create a substantial economic burden. Dietary modification is one effective approach for prevention of osteoporosis in the general population. Recently, B vitamins have been investigated for their possible roles in bone health in human studies. In this review, we provide different lines of evidence and potential mechanisms of individual B vitamin in influencing bone structure, bone quality, bone mass and fracture risk from published peer-reviewed articles. These data support a possible protective role of B vitamins, particularly, B2, B6, folate and B12, in bone health. However, results from the clinical trials have not been promising in supporting the efficacy of B vitamin supplementation in fracture reduction. Future research should continue to investigate the underlying mechanistic pathways and consider interventional studies using dietary regimens with vitamin B enriched foods to avoid potential adverse effects of high-dose vitamin B supplementation. In addition, observational and interventional studies conducted in Asia are limited and thus require more attention due to a steep rise of osteoporosis and hip fracture incidence projected in this part of the world. View Full-Text
Keywords: vitamin B; bone; osteoporosis; fracture vitamin B; bone; osteoporosis; fracture
MDPI and ACS Style

Dai, Z.; Koh, W.-P. B-Vitamins and Bone Health–A Review of the Current Evidence. Nutrients 2015, 7, 3322-3346.

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