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B-Vitamins and Bone Health–A Review of the Current Evidence

by 1,* and 2,*
Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Block MD1, 12 Science Drive 2, Singapore 117549, Singapore
Office of Clinical Sciences, Duke-NUS Graduate Medical School Singapore, Singapore, 8 College Road Level 4, Singapore 169857, Singapore
Authors to whom correspondence should be addressed.
Nutrients 2015, 7(5), 3322-3346;
Received: 14 January 2015 / Revised: 24 April 2015 / Accepted: 27 April 2015 / Published: 7 May 2015
(This article belongs to the Special Issue Nutrition and Bone Health)
Because of ongoing global ageing, there is a rapid worldwide increase in incidence of osteoporotic fractures and the resultant morbidity and mortality associated with these fractures are expected to create a substantial economic burden. Dietary modification is one effective approach for prevention of osteoporosis in the general population. Recently, B vitamins have been investigated for their possible roles in bone health in human studies. In this review, we provide different lines of evidence and potential mechanisms of individual B vitamin in influencing bone structure, bone quality, bone mass and fracture risk from published peer-reviewed articles. These data support a possible protective role of B vitamins, particularly, B2, B6, folate and B12, in bone health. However, results from the clinical trials have not been promising in supporting the efficacy of B vitamin supplementation in fracture reduction. Future research should continue to investigate the underlying mechanistic pathways and consider interventional studies using dietary regimens with vitamin B enriched foods to avoid potential adverse effects of high-dose vitamin B supplementation. In addition, observational and interventional studies conducted in Asia are limited and thus require more attention due to a steep rise of osteoporosis and hip fracture incidence projected in this part of the world. View Full-Text
Keywords: vitamin B; bone; osteoporosis; fracture vitamin B; bone; osteoporosis; fracture
MDPI and ACS Style

Dai, Z.; Koh, W.-P. B-Vitamins and Bone Health–A Review of the Current Evidence. Nutrients 2015, 7, 3322-3346.

AMA Style

Dai Z, Koh W-P. B-Vitamins and Bone Health–A Review of the Current Evidence. Nutrients. 2015; 7(5):3322-3346.

Chicago/Turabian Style

Dai, Zhaoli, and Woon-Puay Koh. 2015. "B-Vitamins and Bone Health–A Review of the Current Evidence" Nutrients 7, no. 5: 3322-3346.

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