Vitamin B12 in Obese Adolescents with Clinical Features of Insulin Resistance
AbstractEmerging evidence indicates an association between obesity, metformin use and reduced vitamin B12 status, which can have serious hematologic, neurologic and psychiatric consequences. This study aimed to examine B12 status in obese adolescents with pre-diabetes and/or clinical features of insulin resistance. Serum B12 was measured using chemiluminescence immunoassay in 103 (43 male, 60 female) obese (mean body mass index (BMI) z-score ± SD (2.36 ± 0.29)), adolescents aged 10 to 17 years, median (range) insulin sensitivity index of 1.27 (0.27 to 3.38) and 13.6% had pre-diabetes. Low B12 (<148 pmol/L) was identified in eight (7.8%) and borderline status (148 to 221 pmol/L) in an additional 25 (24.3%) adolescents. Adolescents with borderline B12 concentrations had higher BMI z-scores compared to those with normal concentrations (2.50 ± 0.22 vs. 2.32 ± 0.30, p = 0.008) or those with low B12 concentration (2.50 ± 0.22 vs. 2.27 ± 0.226, p = 0.041). In conclusion, nearly a third of obese adolescents with clinical insulin resistance had a low or borderline serum B12 status. Therefore, further investigations are warranted to explore the cause and the impact of low B12 status in obese pediatric populations. View Full-Text
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Ho, M.; Halim, J.H.; Gow, M.L.; El-Haddad, N.; Marzulli, T.; Baur, L.A.; Cowell, C.T.; Garnett, S.P. Vitamin B12 in Obese Adolescents with Clinical Features of Insulin Resistance. Nutrients 2014, 6, 5611-5618.
Ho M, Halim JH, Gow ML, El-Haddad N, Marzulli T, Baur LA, Cowell CT, Garnett SP. Vitamin B12 in Obese Adolescents with Clinical Features of Insulin Resistance. Nutrients. 2014; 6(12):5611-5618.Chicago/Turabian Style
Ho, Mandy; Halim, Jocelyn H.; Gow, Megan L.; El-Haddad, Nouhad; Marzulli, Teresa; Baur, Louise A.; Cowell, Chris T.; Garnett, Sarah P. 2014. "Vitamin B12 in Obese Adolescents with Clinical Features of Insulin Resistance." Nutrients 6, no. 12: 5611-5618.