Intestinal Iron Homeostasis and Colon Tumorigenesis
Abstract
:1. Introduction
2. Mechanism of Iron Absorption
3. Increased Systemic Iron Is a Risk Factor for CRC
3.1. Hemochromatosis
3.2. Dietary Consumption
3.3. Mouse Models of CRC
4. Low Iron Is Protective in CRC
5. Altered Local Iron Homeostasis in CRC
5.1. DMT-1
5.2. Transferrin and TfR
5.3. Ferritin
5.4. HEPH
5.5. Hepcidin and FPN
6. Oxidative Stress and CRC
7. Additional Pathways of Iron Induced-Tumorigenesis
7.1. Oncogene Activation
7.2. Tumor Inflammatory Response
7.3. Iron and Microbiota
8. Conclusions
Acknowledgements
Conflicts of Interest
References
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Xue, X.; Shah, Y.M. Intestinal Iron Homeostasis and Colon Tumorigenesis. Nutrients 2013, 5, 2333-2351. https://doi.org/10.3390/nu5072333
Xue X, Shah YM. Intestinal Iron Homeostasis and Colon Tumorigenesis. Nutrients. 2013; 5(7):2333-2351. https://doi.org/10.3390/nu5072333
Chicago/Turabian StyleXue, Xiang, and Yatrik M. Shah. 2013. "Intestinal Iron Homeostasis and Colon Tumorigenesis" Nutrients 5, no. 7: 2333-2351. https://doi.org/10.3390/nu5072333