Next Article in Journal
Echium Oil Reduces Plasma Triglycerides by Increasing Intravascular Lipolysis in apoB100-Only Low Density Lipoprotein (LDL) Receptor Knockout Mice
Next Article in Special Issue
Iron Deprivation in Cancer––Potential Therapeutic Implications
Previous Article in Journal
The Role of Vitamin D in Blood Pressure, Endothelial and Renal Function in Postmenopausal Women
Previous Article in Special Issue
Intestinal Iron Homeostasis and Colon Tumorigenesis
Article Menu

Export Article

Open AccessReview

Influence of microRNA on the Maintenance of Human Iron Metabolism

Department of Nutritional Sciences, Oklahoma State University, Stillwater, OK 74078, USA
Author to whom correspondence should be addressed.
Nutrients 2013, 5(7), 2611-2628;
Received: 2 May 2013 / Revised: 19 June 2013 / Accepted: 24 June 2013 / Published: 10 July 2013
(This article belongs to the Special Issue Dietary Iron and Human Health)
PDF [495 KB, uploaded 10 July 2013]


Iron is an essential nutrient critical for many cellular functions including DNA synthesis, ATP generation, and cellular proliferation. Though essential, excessive iron may contribute to the generation of free radicals capable of damaging cellular lipids, proteins, and nucleic acids. As such, the maintenance and control of cellular iron homeostasis is critical to prevent either iron deficiency or iron toxicity conditions. The maintenance of cellular iron homeostasis is largely coordinated by a family of cytosolic RNA binding proteins known as Iron Regulatory Proteins (IRP) that function to post-transcriptionally control the translation and/or stability of mRNA encoding proteins required for iron uptake, storage, transport, and utilization. More recently, a class of small non-coding RNA known as microRNA (miRNA) has also been implicated in the control of iron metabolism. To date, miRNA have been demonstrated to post-transcriptionally regulate the expression of genes associated with iron acquisition (transferrin receptor and divalent metal transporter), iron export (ferroportin), iron storage (ferritin), iron utilization (ISCU), and coordination of systemic iron homeostasis (HFE and hemojevelin). Given the diversity of miRNA and number of potential mRNA targets, characterizing factors that contribute to alterations in miRNA expression, biogenesis, and processing will enhance our understanding of mechanisms by which cells respond to changes in iron demand and/or iron availability to control cellular iron homeostasis. View Full-Text
Keywords: diet; cell metabolism; iron homeostasis; microRNA regulation diet; cell metabolism; iron homeostasis; microRNA regulation

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Davis, M.; Clarke, S. Influence of microRNA on the Maintenance of Human Iron Metabolism. Nutrients 2013, 5, 2611-2628.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top