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Selenium in Bone Health: Roles in Antioxidant Protection and Cell Proliferation

Grand Forks Human Nutrition Research Center, Agricultural Research Service, United States Department of Agriculture, Grand Forks, ND 58202, USA
Author to whom correspondence should be addressed.
Nutrients 2013, 5(1), 97-110;
Received: 28 November 2012 / Revised: 17 December 2012 / Accepted: 3 January 2013 / Published: 10 January 2013
(This article belongs to the Special Issue Dietary Selenium and Health)
PDF [477 KB, uploaded 10 January 2013]


Selenium (Se) is an essential trace element for humans and animals, and several findings suggest that dietary Se intake may be necessary for bone health. Such findings may relate to roles of Se in antioxidant protection, enhanced immune surveillance and modulation of cell proliferation. Elucidation of the mechanisms by which Se supports these cellular processes can lead to a better understanding of the role of this nutrient in normal bone metabolism. This article reviews the current knowledge concerning the molecular functions of Se relevant to bone health. View Full-Text
Keywords: antioxidant; bone health; cell proliferation antioxidant; bone health; cell proliferation

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Zeng, H.; Cao, J.J.; Combs, G.F., Jr. Selenium in Bone Health: Roles in Antioxidant Protection and Cell Proliferation. Nutrients 2013, 5, 97-110.

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