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Open AccessArticle

Anti-Obesity Effects of Onion Extract in Zucker Diabetic Fatty Rats

Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata 997-8555, Japan
Ryusendo Co., Ltd., Toshima-ku, Tokyo 171-0021, Japan
Author to whom correspondence should be addressed.
Nutrients 2012, 4(10), 1518-1526;
Received: 17 August 2012 / Revised: 28 September 2012 / Accepted: 15 October 2012 / Published: 22 October 2012
(This article belongs to the Special Issue Nutrition and Diabetes)
PDF [434 KB, uploaded 22 October 2012]


Anti-obesity effects of onion extract were determined in obesity and diabetes-prone Zucker diabetic fatty rats by measuring the efficacy of markers concerned with diabetes and obesity. Body and adipose tissue weights in 5% of onion extract-fed group were found to be significantly lower than the control group without onion extract. Fasting blood glucose and HOMA-IR levels were also improved, although the serum insulin and leptin levels did not show any remarkable difference. Serum triglyceride and free fatty acid levels in both the 3% and 5%-fed group were found to be reduced compared to the control group. Additionally the feeding of the onion extract increased the glucose tolerance. These results suggest that dietary onion extract is beneficial for improving diabetes by decreasing lipid levels. We also examined differentiation ability of rat white preadipocyte cells using the onion extract and its sulfur-containing components. Cycloalliin, S-methyl-l-cysteine, S-propyl-l-cysteine sulfoxide, dimethyl trisulfide, especially S-methyl-l-cysteine sulfoxide were reported to be effective in inhibiting formation of oil drop in the cells, suggesting that these compounds may be involved in the anti-obesity effect of the onion extract. View Full-Text
Keywords: onion; anti-obesity; type 2 diabetes; Zucker rat; sulfur-containing compound onion; anti-obesity; type 2 diabetes; Zucker rat; sulfur-containing compound

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Yoshinari, O.; Shiojima, Y.; Igarashi, K. Anti-Obesity Effects of Onion Extract in Zucker Diabetic Fatty Rats. Nutrients 2012, 4, 1518-1526.

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