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Nutrients
Volume 17
Issue 4
10.3390/nu17040620
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Article

The Importance of Nutriepigenetics in Older Adults with Inflammatory Bowel Disease

by
Ana-Gabriela Prada
1,
Costina Daniela Gîță
1,2,
Sandra Monica Gîdei
1,2,
Doina Istratescu
1,
Tudor Stroie
1,3,
Sorina Maria Aurelian
1,2,*,
Gabriel Ioan Prada
1,4,
Ovidiu Nicolae Penes
1,
Anca Lucia Pop
1 and
Mihai Mircea Diculescu
1,3
1
Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania
2
Department of Geriatrics, Hospital of Chronic Diseases “Sf. Luca”, 041915 Bucharest, Romania
3
Department of Gastroenterology and Hepatology, Fundeni Clinical Institute, 022328 Bucharest, Romania
4
Department of Geriatrics and Gerontology, “Ana Aslan” National Institute of Gerontology and Geriatrics, 011241 Bucharest, Romania
*
Author to whom correspondence should be addressed.
Nutrients 2025, 17(4), 620; https://doi.org/10.3390/nu17040620
Submission received: 10 January 2025 / Revised: 4 February 2025 / Accepted: 7 February 2025 / Published: 9 February 2025
(This article belongs to the Special Issue Nutrigenetic, Nutrigenomic & Nutriepigenetic Approaches in Age Management Interventions)
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Abstract

Background: Nutriepigenetics, the study of nutritional effects on gene expression, offers new insights into the clinical variability and relapse frequency of inflammatory bowel disease (IBD). As older adult populations are frequently unrepresented in the literature regarding their nutrition’s influence on their gene expression, we considered that studying this aspect would shed light on this population group. Materials and Methods: We conducted a prospective observational study on 60 IBD patients, categorized by age, residence, and nutrition access. Patients were grouped according to age groups (“young”-old—65–74 years old and old-old—75–86 years old), gender, IBD type, organic diet preference, Simple Clinical Colitis Activity Index (SCCAI), and Harvey-Bradshaw Index (HBI) at diagnosis and after diet change. All patients were followed up at the Fundeni Clinical Institute in Bucharest, Romania, and received personalized dietary recommendations, in accordance with the European guidelines. Results: Our findings revealed that a diet that was predominantly organic had a positive impact on decreasing the number of relapse episodes, irrespective of IBD type. Predominant diets, rich in dairy and saturated fats, mostly from non-organic sources, exacerbated inflammation and increased the frequencies of relapses. Conclusions: Older adult patients who adopted a predominantly organic diet had a reduction in frequency of relapse episodes, thus proving that diet is an important part of the treatment regimen of this population.
Keywords: nutriepigenetics; older adult; inflammatory bowel disease; organic diet; geographical distribution nutriepigenetics; older adult; inflammatory bowel disease; organic diet; geographical distribution

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MDPI and ACS Style

Prada, A.-G.; Gîță, C.D.; Gîdei, S.M.; Istratescu, D.; Stroie, T.; Aurelian, S.M.; Prada, G.I.; Penes, O.N.; Pop, A.L.; Diculescu, M.M. The Importance of Nutriepigenetics in Older Adults with Inflammatory Bowel Disease. Nutrients 2025, 17, 620. https://doi.org/10.3390/nu17040620

AMA Style

Prada A-G, Gîță CD, Gîdei SM, Istratescu D, Stroie T, Aurelian SM, Prada GI, Penes ON, Pop AL, Diculescu MM. The Importance of Nutriepigenetics in Older Adults with Inflammatory Bowel Disease. Nutrients. 2025; 17(4):620. https://doi.org/10.3390/nu17040620

Chicago/Turabian Style

Prada, Ana-Gabriela, Costina Daniela Gîță, Sandra Monica Gîdei, Doina Istratescu, Tudor Stroie, Sorina Maria Aurelian, Gabriel Ioan Prada, Ovidiu Nicolae Penes, Anca Lucia Pop, and Mihai Mircea Diculescu. 2025. "The Importance of Nutriepigenetics in Older Adults with Inflammatory Bowel Disease" Nutrients 17, no. 4: 620. https://doi.org/10.3390/nu17040620

APA Style

Prada, A.-G., Gîță, C. D., Gîdei, S. M., Istratescu, D., Stroie, T., Aurelian, S. M., Prada, G. I., Penes, O. N., Pop, A. L., & Diculescu, M. M. (2025). The Importance of Nutriepigenetics in Older Adults with Inflammatory Bowel Disease. Nutrients, 17(4), 620. https://doi.org/10.3390/nu17040620

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