Unveiling the Growth Impact of Probiotics in Neonates: To BEgin or Not to BEgin?
Abstract
:1. Introduction
2. Methods
2.1. Study Design
2.2. Search Strategy
2.3. Inclusion and Exclusion Criteria
2.4. Article Screening
2.5. Data Extraction
2.6. Statistical Analysis
3. Results
3.1. Study Selection
3.2. Study Characteristics
3.3. Forest Plot and Sub-Group Analysis
4. Discussion
5. Policy Implications
6. Conclusions
Limitations and Future Directions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Criteria | Inclusion | Exclusion |
---|---|---|
Population | Neonates (term and preterm) receiving probiotics, with a focus on weight gain outcomes. | Neonates with congenital or severe metabolic disorders affecting weight gain unrelated to probiotics. |
Intervention | Probiotics administered (oral or enteral), including single-strain and multi-strain probiotics (e.g., Lactobacillus reuteri, Bifidobacterium species). | Studies not involving probiotics, or those without clear intervention details. |
Outcome Measures | Neonatal weight gain measured at specific intervals (e.g., daily, weekly). | Studies that do not report weight gain as an outcome measure. |
Study Type | Randomized controlled trials (RCTs) and observational studies. | Non-randomized studies without a clear outcome or methodology. |
Age | Studies involving neonates and up to 6 months old. | Older than 6 months of age. |
Publication Type | Published in peer-reviewed journals. | Articles not published in peer-reviewed journals. |
Data Completeness | Studies with complete data on probiotic strain, dosage, and weight gain outcomes. | Studies with insufficient data on the probiotic strain, dosage, or weight gain outcomes. |
No | Authors | Year | Region | Country | Intervention | Sample Size |
---|---|---|---|---|---|---|
1 | Hays et al. [8] | 2016 | Lyon, Montpellier, and Bron | France | Probiotics (lactic + longum) | 197 |
2 | Totsu et al. [9] | 2018 | Tokyo | Japan | OLB6378 strain | 207 |
3 | Sari et al. [10] | 2012 | Ankara | Turkey | Lactobacillus sporogenes | 174 |
4 | Cui et al. [11] | 2019 | Shenyang | China | Lactobacillus reuteri DSM 17938 | 114 |
5 | Oshiro et al. [12] | 2019 | Tokyo | Japan | Bifidobacterium | 35 |
6 | Totsu et al. [13] | 2014 | Tokyo | Japan | Bifidobacterium bifidum OLB6378 | 283 |
7 | Shashidhar et al. [14] | 2017 | Bangalore | India | Lactobacillus acidophilus, Lactobacillus rhamnosus, Bifidobacterium longum and Saccharomyces boulardii | 104 |
8 | Xu et al. [15] | 2016 | Shenyang | China | S. boulardii | 125 |
9 | Moni et al. [16] | 2017 | Dhaka | Bangladesh | Lactobacillus and Bifidobacterium | 65 |
10 | Nouri et al. [17] | 2015 | Yazd | Iran | Lactobacillus reuteri | 60 |
11 | Patole et al. [18] | 2014 | Sydney | Australia | B. breve M16V | 159 |
12 | Wejryd et al. [19] | 2019 | Linköping | Sweden | L. reuteri | 134 |
13 | Van et al. [20] | 2014 | Tygerberg | South Africa | Lactobacillus rhamnosus GG and Bifidobacterium | 110 |
14 | Demirel et al. [21] | 2013 | Ankara | Turkey | Saccharomyces boulardii | 271 |
15 | Jacobs et al. [22] | 2017 | Melbourne | Australia | B. infantis, S. thermophilus, and B. lactis | 1099 |
16 | Serce et al. [23] | 2013 | Istanbul | Turkey | Saccharomyces boulardii | 208 |
17 | Al-Hosni et al. [24] | 2012 | Burlington | USA | Lactobacillus rhamnosus GG and Bifidobacterium | 101 |
18 | Sari et al. [25] | 2011 | Ankara | Turkey | L. sporogenes | 221 |
19 | Sowden et al. [26] | 2022 | Cape Town | South Africa | LabinicTM | 200 |
20 | Alshaikh et al. [27] | 2022 | Calgary | Canada | Multi-strain probiotics | 62 |
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Aslan, M.T.; Ersözlü, Y.; Özen, M. Unveiling the Growth Impact of Probiotics in Neonates: To BEgin or Not to BEgin? Nutrients 2025, 17, 1867. https://doi.org/10.3390/nu17111867
Aslan MT, Ersözlü Y, Özen M. Unveiling the Growth Impact of Probiotics in Neonates: To BEgin or Not to BEgin? Nutrients. 2025; 17(11):1867. https://doi.org/10.3390/nu17111867
Chicago/Turabian StyleAslan, Mustafa Törehan, Yasemin Ersözlü, and Metehan Özen. 2025. "Unveiling the Growth Impact of Probiotics in Neonates: To BEgin or Not to BEgin?" Nutrients 17, no. 11: 1867. https://doi.org/10.3390/nu17111867
APA StyleAslan, M. T., Ersözlü, Y., & Özen, M. (2025). Unveiling the Growth Impact of Probiotics in Neonates: To BEgin or Not to BEgin? Nutrients, 17(11), 1867. https://doi.org/10.3390/nu17111867