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Volume 16
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10.3390/nu16050656
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Review

Influence of Androgen Deprivation Therapy on the Development of Sarcopenia in Patients with Prostate Cancer: A Systematic Review

by
Marta Stelmach-Mardas
1,*,
Wojciech Warchoł
2,†,
Aleksandra Garczyk
1,†,
Emilia Warchoł
1,
Jolanta Korczak
3,
Maria Litwiniuk
4,
Beata Brajer-Luftmann
5 and
Marcin Mardas
6
1
Department of Obesity Treatment, Metabolic Disorders and Clinical Dietetics, Poznan University of Medical Sciences, 60-569 Poznan, Poland
2
Department of Ophthalmology and Optometry, Poznan University of Medical Sciences, 60-806 Poznan, Poland
3
Department of Chemotherapy, The Greater Poland Cancer Center, 61-866 Poznan, Poland
4
Department of Cancer Pathology and Prevention, Poznan University of Medical Sciences, 61-866 Poznan, Poland
5
Department of Pulmonology, Allergology and Pulmonary Oncology, Poznan University of Medical Sciences, 60-569 Poznan, Poland
6
Department of Gynecological Oncology, Institute of Oncology, Poznan University of Medical Sciences, 60-569 Poznan, Poland
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Nutrients 2024, 16(5), 656; https://doi.org/10.3390/nu16050656
Submission received: 18 January 2024 / Revised: 22 February 2024 / Accepted: 23 February 2024 / Published: 26 February 2024
(This article belongs to the Section Nutrition Methodology & Assessment)
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Abstract

The changes in body composition during androgen deprivation therapy (ADT) in patients suffering from prostate cancer (PCa) are recognized by professionals more often as biomarker for effective treatment. The aim of this study was to investigate the impact of ADT on the sarcopenia development in PCa. The following databases were used: PubMed, Embase, Web of Science and Scopus databases. Out of 2183 studies, 7 were included in this review. The fixed-effect model was used in the meta-analysis. A significant increase in SATI (Subcutaneous Adipose Tissue Index) of 0.32 (95% CI: 0.13–0.51) p = 0.001, decrease in SMI (Skeletal Muscle Index) of −0.38 (95% CI: −0.57 to −0.19) p < 0.0001, and SMD (Skeletal Muscle Density) of −0.46 (95% CI: −0.69 to −0.24) p < 0.0001 were observed. No statistical association was visible between ADT and changes in BMI (Body Mass Index), 0.05 (95% CI: −0.18–0.28), p = 0.686, and VATI (Visceral Adipose Tissue Index): 0.17 (95% CI: −0.02 to 0.37), p = 0.074. In conclusion, the ADT significantly contributes to the body composition changes and sarcopenia development.
Keywords: androgen deprivation therapy; ADT; sarcopenia; prostate cancer; prostatic neoplasm; systematic review androgen deprivation therapy; ADT; sarcopenia; prostate cancer; prostatic neoplasm; systematic review

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MDPI and ACS Style

Stelmach-Mardas, M.; Warchoł, W.; Garczyk, A.; Warchoł, E.; Korczak, J.; Litwiniuk, M.; Brajer-Luftmann, B.; Mardas, M. Influence of Androgen Deprivation Therapy on the Development of Sarcopenia in Patients with Prostate Cancer: A Systematic Review. Nutrients 2024, 16, 656. https://doi.org/10.3390/nu16050656

AMA Style

Stelmach-Mardas M, Warchoł W, Garczyk A, Warchoł E, Korczak J, Litwiniuk M, Brajer-Luftmann B, Mardas M. Influence of Androgen Deprivation Therapy on the Development of Sarcopenia in Patients with Prostate Cancer: A Systematic Review. Nutrients. 2024; 16(5):656. https://doi.org/10.3390/nu16050656

Chicago/Turabian Style

Stelmach-Mardas, Marta, Wojciech Warchoł, Aleksandra Garczyk, Emilia Warchoł, Jolanta Korczak, Maria Litwiniuk, Beata Brajer-Luftmann, and Marcin Mardas. 2024. "Influence of Androgen Deprivation Therapy on the Development of Sarcopenia in Patients with Prostate Cancer: A Systematic Review" Nutrients 16, no. 5: 656. https://doi.org/10.3390/nu16050656

APA Style

Stelmach-Mardas, M., Warchoł, W., Garczyk, A., Warchoł, E., Korczak, J., Litwiniuk, M., Brajer-Luftmann, B., & Mardas, M. (2024). Influence of Androgen Deprivation Therapy on the Development of Sarcopenia in Patients with Prostate Cancer: A Systematic Review. Nutrients, 16(5), 656. https://doi.org/10.3390/nu16050656

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