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Nutrients
Volume 16
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10.3390/nu16234100
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Review

The Potential Role of Dietary Polyphenols in the Prevention and Treatment of Acute Leukemia

by
Fatemeh Fakhar
1,
Kiana Mohammadian
1,
Shayan Keramat
2,3 and
Agata Stanek
2,4,*
1
Division of Hematology and Blood Banking, Department of Medical Laboratory Sciences, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz 71348, Iran
2
VAS-European Independent Foundation in Angiology/Vascular Medicine, Via GB Grassi 74, 20157 Milan, Italy
3
Support Association of Patients of Buerger’s Disease, Buerger’s Disease NGO, Mashhad 9183785195, Iran
4
Department of Internal Medicine, Metabolic Diseases and Angiology, Faculty of Health Sciences in Katowice, Medical University of Silesia, Upper Silesian Medical Center, Ziołowa 45/47 St., 40-055 Katowice, Poland
*
Author to whom correspondence should be addressed.
Nutrients 2024, 16(23), 4100; https://doi.org/10.3390/nu16234100
Submission received: 28 October 2024 / Revised: 22 November 2024 / Accepted: 26 November 2024 / Published: 28 November 2024
(This article belongs to the Special Issue Enhancing Human Health Through Plant-Based Dietary Bioactive Compounds)
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Highlights

  • The consumption of dietary polyphenols may be effective in the prevention of acute leukemia.
  • Dietary polyphenols, when combined with standard treatments for acute leukemia, can mitigate the associated side effects.
  • The encapsulation of dietary polyphenols, either in combination with standard treatments or independently, can facilitate their intake and serve as a dietary supplement for preventive purposes.
  • Due to the progressive nature of acute leukemia, the therapeutic application of dietary polyphenols has been largely overlooked in clinical trials.

Abstract

Acute leukemia is a prevalent cancer worldwide and is classified into two distinct forms. Currently, various therapies have been developed for this disease; however, the issues of recurrence, resistance to treatment, and adverse effects require the exploration of novel treatments. Polyphenols, classified into four categories, are secondary metabolites originating from plants that demonstrate diverse metabolic features such as anticancer, anti-inflammatory, and antioxidant activities. Consequently, they have attracted attention for therapeutic and preventive measures. Research indicates that dietary polyphenols can mitigate the disease burden of acute leukemias by influencing the molecular pathways associated with the disease and its inflammatory processes. Furthermore, owing to their antioxidant properties, they can reduce the amounts of reactive oxygen species generated from the disrupted molecular pathways in these malignancies. The therapeutic actions of polyphenols can facilitate disease recovery by interrupting the cell cycle and causing apoptosis by activating pro-apoptotic genes. In conclusion, the intake of dietary polyphenols, due to their convenience and availability, coupled with the positive outcomes associated with their use in conjunction with conventional therapies, may function as an efficient therapeutic and preventive measure for acute leukemia.
Keywords: dietary polyphenols; acute leukemia; anticancer; anti-inflammatory; antioxidant dietary polyphenols; acute leukemia; anticancer; anti-inflammatory; antioxidant

Share and Cite

MDPI and ACS Style

Fakhar, F.; Mohammadian, K.; Keramat, S.; Stanek, A. The Potential Role of Dietary Polyphenols in the Prevention and Treatment of Acute Leukemia. Nutrients 2024, 16, 4100. https://doi.org/10.3390/nu16234100

AMA Style

Fakhar F, Mohammadian K, Keramat S, Stanek A. The Potential Role of Dietary Polyphenols in the Prevention and Treatment of Acute Leukemia. Nutrients. 2024; 16(23):4100. https://doi.org/10.3390/nu16234100

Chicago/Turabian Style

Fakhar, Fatemeh, Kiana Mohammadian, Shayan Keramat, and Agata Stanek. 2024. "The Potential Role of Dietary Polyphenols in the Prevention and Treatment of Acute Leukemia" Nutrients 16, no. 23: 4100. https://doi.org/10.3390/nu16234100

APA Style

Fakhar, F., Mohammadian, K., Keramat, S., & Stanek, A. (2024). The Potential Role of Dietary Polyphenols in the Prevention and Treatment of Acute Leukemia. Nutrients, 16(23), 4100. https://doi.org/10.3390/nu16234100

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