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Volume 16
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10.3390/nu16172951
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Article

Multi-Omics Profiles of Small Intestine Organoids in Reaction to Breast Milk and Different Infant Formula Preparations

by
Xianli Wang
1,†,
Shangzhi Yang
2,†,
Chengdong Zheng
3,†,
Chenxuan Huang
2,
Haiyang Yao
2,
Zimo Guo
2,
Yilun Wu
2,
Zening Wang
4,
Zhenyang Wu
2,
Ruihong Ge
1,
Wei Cheng
1,
Yuanyuan Yan
1,
Shilong Jiang
3,
Jianguo Sun
3,
Xiaoguang Li
5,
Qinggang Xie
3,* and
Hui Wang
5,*
1
School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
2
School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China
3
Heilongjiang Firmus Dairy Co., Ltd., C-16, 10A Jiuxianqiao Rd., Chaoyang, Beijing 100015, China
4
Institutes of Biomedical Sciences, Fudan University, 131 Dongan Road, Shanghai 200032, China
5
State Key Laboratory of Systems Medicine for Cancer, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Nutrients 2024, 16(17), 2951; https://doi.org/10.3390/nu16172951
Submission received: 16 July 2024 / Revised: 27 August 2024 / Accepted: 28 August 2024 / Published: 2 September 2024
(This article belongs to the Topic Advances in Animal-Derived Non-Cow Milk and Milk Products)
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Abstract

Ensuring optimal infant nutrition is crucial for the health and development of children. Many infants aged 0–6 months are fed with infant formula rather than breast milk. Research on cancer cell lines and animal models is limited to examining the nutrition effects of formula and breast milk, as it does not comprehensively consider absorption, metabolism, and the health and social determinants of the infant and its physiology. Our study utilized small intestine organoids induced from human embryo stem cell (ESC) to compare the nutritional effects of breast milk from five donors during their postpartum lactation period of 1–6 months and three types of Stage 1 infant formulae from regular retail stores. Using transcriptomics and untargeted metabolomics approaches, we focused on the differences such as cell growth and development, cell junctions, and extracellular matrix. We also analyzed the roles of pathways including AMPK, Hippo, and Wnt, and identified key genes such as ALPI, SMAD3, TJP1, and WWTR1 for small intestine development. Through observational and in-vitro analysis, our study demonstrates ESC-derived organoids might be a promising model for exploring nutritional effects and underlying mechanisms.
Keywords: organoids; transcriptome; metabolomics; infant formulas; small intestine; growth development organoids; transcriptome; metabolomics; infant formulas; small intestine; growth development

Share and Cite

MDPI and ACS Style

Wang, X.; Yang, S.; Zheng, C.; Huang, C.; Yao, H.; Guo, Z.; Wu, Y.; Wang, Z.; Wu, Z.; Ge, R.; et al. Multi-Omics Profiles of Small Intestine Organoids in Reaction to Breast Milk and Different Infant Formula Preparations. Nutrients 2024, 16, 2951. https://doi.org/10.3390/nu16172951

AMA Style

Wang X, Yang S, Zheng C, Huang C, Yao H, Guo Z, Wu Y, Wang Z, Wu Z, Ge R, et al. Multi-Omics Profiles of Small Intestine Organoids in Reaction to Breast Milk and Different Infant Formula Preparations. Nutrients. 2024; 16(17):2951. https://doi.org/10.3390/nu16172951

Chicago/Turabian Style

Wang, Xianli, Shangzhi Yang, Chengdong Zheng, Chenxuan Huang, Haiyang Yao, Zimo Guo, Yilun Wu, Zening Wang, Zhenyang Wu, Ruihong Ge, and et al. 2024. "Multi-Omics Profiles of Small Intestine Organoids in Reaction to Breast Milk and Different Infant Formula Preparations" Nutrients 16, no. 17: 2951. https://doi.org/10.3390/nu16172951

APA Style

Wang, X., Yang, S., Zheng, C., Huang, C., Yao, H., Guo, Z., Wu, Y., Wang, Z., Wu, Z., Ge, R., Cheng, W., Yan, Y., Jiang, S., Sun, J., Li, X., Xie, Q., & Wang, H. (2024). Multi-Omics Profiles of Small Intestine Organoids in Reaction to Breast Milk and Different Infant Formula Preparations. Nutrients, 16(17), 2951. https://doi.org/10.3390/nu16172951

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