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Nutrients
Volume 16
Issue 13
10.3390/nu16132055
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Article

Preoperative Multistrain Probiotic Supplementation Does Not Affect Body Weight Changes or Cardiometabolic Risk Factors in Bariatrics: Randomized, Double-Blind, Placebo-Controlled Clinical Trial

by
Marta Potrykus
1,
Sylwia Czaja-Stolc
2,*,
Marta Stankiewicz
2,
Michał Szymański
1,
Igor Łoniewski
3,4,
Łukasz Kaska
5 and
Monika Proczko-Stepaniak
1
1
Department of Oncological, Transplant, and General Surgery, Medical University of Gdansk, 80-211 Gdańsk, Poland
2
Department of Clinical Nutrition and Dietetics, Medical University of Gdansk, 80-211 Gdańsk, Poland
3
Sanprobi sp. z o.o. sp. k., 70-535 Szczecin, Poland
4
Department of Biochemical Science, Pomeranian Medical University in Szczecin, 71-460 Szczecin, Poland
5
Independent Public Health Care Center of the Ministry of Internal Affairs and Administration, 80-210 Gdańsk, Poland
*
Author to whom correspondence should be addressed.
Nutrients 2024, 16(13), 2055; https://doi.org/10.3390/nu16132055
Submission received: 1 June 2024 / Revised: 25 June 2024 / Accepted: 26 June 2024 / Published: 27 June 2024
(This article belongs to the Special Issue Metabolic Features and Nutritional Interventions in Chronic Diseases)
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Abstract

Emerging evidence suggests that microbiota plays a crucial role in the development, progression, and therapeutic options in obesity and its comorbidities. This study assessed preoperative probiotic therapy’s impact on bariatric treatment outcomes. A 12-week randomized, double-blind, placebo-controlled trial with 48 patients undergoing bariatric surgery was conducted. Participants received probiotics—Sanprobi Barrier—which contained nine strains of bacteria: Bifidobacterium bifidum W23, Bifidobacterium lactis W51 and W52, Lactobacillus acidophilus W37, Levilactobacillus brevis W63, Lacticaseibacillus casei W56, Ligilactobacillus salivarius W24, Lactococcus lactis W19, and Lactococcus lactis W58. Primary outcomes included excess body weight loss, body weight loss, and excess body mass index loss, with secondary objectives focusing on metabolic profiles. Surgical treatment of obesity significantly improved anthropometric and metabolic parameters. No significant differences were observed in primary outcomes or in secondary outcomes between groups at any time point post-surgery. Preoperative probiotics administration did not affect clinical outcomes 1, 3, or 6 months following bariatric surgery.
Keywords: probiotics; intestinal microbiota; bariatric surgery; obesity; metabolic disorders; weight loss probiotics; intestinal microbiota; bariatric surgery; obesity; metabolic disorders; weight loss

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MDPI and ACS Style

Potrykus, M.; Czaja-Stolc, S.; Stankiewicz, M.; Szymański, M.; Łoniewski, I.; Kaska, Ł.; Proczko-Stepaniak, M. Preoperative Multistrain Probiotic Supplementation Does Not Affect Body Weight Changes or Cardiometabolic Risk Factors in Bariatrics: Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Nutrients 2024, 16, 2055. https://doi.org/10.3390/nu16132055

AMA Style

Potrykus M, Czaja-Stolc S, Stankiewicz M, Szymański M, Łoniewski I, Kaska Ł, Proczko-Stepaniak M. Preoperative Multistrain Probiotic Supplementation Does Not Affect Body Weight Changes or Cardiometabolic Risk Factors in Bariatrics: Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Nutrients. 2024; 16(13):2055. https://doi.org/10.3390/nu16132055

Chicago/Turabian Style

Potrykus, Marta, Sylwia Czaja-Stolc, Marta Stankiewicz, Michał Szymański, Igor Łoniewski, Łukasz Kaska, and Monika Proczko-Stepaniak. 2024. "Preoperative Multistrain Probiotic Supplementation Does Not Affect Body Weight Changes or Cardiometabolic Risk Factors in Bariatrics: Randomized, Double-Blind, Placebo-Controlled Clinical Trial" Nutrients 16, no. 13: 2055. https://doi.org/10.3390/nu16132055

APA Style

Potrykus, M., Czaja-Stolc, S., Stankiewicz, M., Szymański, M., Łoniewski, I., Kaska, Ł., & Proczko-Stepaniak, M. (2024). Preoperative Multistrain Probiotic Supplementation Does Not Affect Body Weight Changes or Cardiometabolic Risk Factors in Bariatrics: Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Nutrients, 16(13), 2055. https://doi.org/10.3390/nu16132055

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