Proteomic Mediators of Overall Cardiovascular Health on All-Cause Mortality
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Population
2.2. Cardiovascular Health
2.3. Proteomic Assessment
2.4. Statistic Analysis
3. Results
3.1. Association of Plasma Proteins with Cardiovascular Health
3.2. Plasma Proteins Mediate the Association between CVH and Mortality
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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All | Tertile 1 Score 0–6 | Tertile 2 Score 7–8 | Tertile 3 Score 9–12 | p | |
---|---|---|---|---|---|
n | 703 | 191 | 275 | 237 | |
Age (years) | 73.3 (6.24) | 73.6 (6.35) | 73.5 (6.20) | 72.9 (6.21) | 0.479 |
Female (%) | 54.2 | 56.0 | 56.4 | 50.2 | 0.318 |
Bagno a Ripoli (%) | 52.5 | 52.4 | 51.6 | 53.6 | 0.907 |
Creatinine clearance (mL/minute) | 77.8 (24.9) | 75.9 (24.2) | 76.9 (23.5) | 80.5 (26.8) | 0.123 |
Cardiovascular Health (CVH score) | 7.61 (1.90) | 5.25 (1.04) | 7.48 (0.50) | 9.67 (0.85) | <0.001 |
BMI (kg/m2) | 27.5 (4.03) | 29.6 (4.27) | 27.7 (3.94) | 25.6 (2.93) | <0.001 |
Fasting Glucose (mg/dL) | 95.4 (24.3) | 109.3 (32.2) | 92.8 (21.6) | 87.3 (12.3) | <0.001 |
Total cholesterol (mg/dL) | 219.9 (38.3) | 234.0 (38.38) | 223.9 (35.2) | 204.0 (36.0) | <0.001 |
Mediterranean diet score | 4.52 (1.63) | 3.79 (1.58) | 4.47 (1.56) | 5.17 (1.48) | <0.001 |
Systolic blood pressure (mmHg) | 150.0 (19.3) | 154.3 (16.0) | 152.1 (19.2) | 144.0 (20.4) | <0.001 |
Diastolic blood pressure (mmHg) | 84.0 (8.45) | 85.9 (7.80) | 84.4 (8.15) | 82.0 (8.90) | <0.001 |
Physical activity (%) | <0.001 | ||||
Low | 15.2 | 32.5 | 14.2 | 2.5 | |
Medium | 45.1 | 53.4 | 51.6 | 30.8 | |
High | 39.7 | 14.1 | 34.2 | 66.7 | |
Smoking (%) | <0.001 | ||||
Never smoked | 57.2 | 42.4 | 57.1 | 69.2 | |
Former smoker | 28.2 | 30.4 | 29.5 | 24.9 | |
Current smoker | 14.7 | 27.2 | 13.5 | 5.9 |
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Tanaka, T.; Talegawkar, S.A.; Jin, Y.; Candia, J.; Fantoni, G.; Bandinelli, S.; Ferrucci, L. Proteomic Mediators of Overall Cardiovascular Health on All-Cause Mortality. Nutrients 2023, 15, 781. https://doi.org/10.3390/nu15030781
Tanaka T, Talegawkar SA, Jin Y, Candia J, Fantoni G, Bandinelli S, Ferrucci L. Proteomic Mediators of Overall Cardiovascular Health on All-Cause Mortality. Nutrients. 2023; 15(3):781. https://doi.org/10.3390/nu15030781
Chicago/Turabian StyleTanaka, Toshiko, Sameera A. Talegawkar, Yichen Jin, Julián Candia, Giovanna Fantoni, Stefania Bandinelli, and Luigi Ferrucci. 2023. "Proteomic Mediators of Overall Cardiovascular Health on All-Cause Mortality" Nutrients 15, no. 3: 781. https://doi.org/10.3390/nu15030781