Effect of Malaria on Blood Levels of Vitamin E: A Systematic Review and Meta-Analysis
Abstract
:1. Introduction
2. Methods
2.1. Registration, Guidelines for Reporting, and Review Questions
2.2. Eligibility Criteria
2.3. Search Strategy
2.4. Study Selection
2.5. Data Extraction
2.6. Quality Assessment
2.7. Data Synthesis
3. Results
3.1. Search Results
3.2. Characteristics and Critical Appraisal of the Studies
3.3. Vitamin E Levels in Malaria Patients Compared with Those Who Were Not Infected
3.4. Difference in Vitamin E Levels between Patients with Severe Malaria and Those Experiencing Less Severe Forms of the Disease
3.5. Difference in Vitamin E Levels among Patients Suffering from either P. falciparum or P. vivax Malaria
3.6. Sensitivity Analysis
3.7. Publication Bias
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Characteristics | n. (23) | % |
---|---|---|
Year of publication | ||
2011–2022 | 9 | 39.1 |
2000–2010 | 7 | 30.4 |
Before 2000 | 7 | 30.4 |
Study designs | ||
Case-control studies | 11 | 47.8 |
Cross-sectional studies | 10 | 43.5 |
Cohort studies | 2 | 8.70 |
Study areas | ||
Africa | 13 | 56.5 |
Nigeria | 12 | 92.3 |
Kenya | 1 | 7.70 |
Asia | 8 | 34.8 |
India | 5 | 62.5 |
Thailand | 2 | 25.0 |
Vietnam | 1 | 12.5 |
Europe | 2 | 8.70 |
Plasmodium spp. | ||
P. falciparum | 16 | 69.6 |
P. falciparum, P. vivax | 4 | 17.4 |
P. falciparum, P. vivax, P. ovale | 1 | 4.34 |
Not specified | 2 | 8.70 |
Participants | ||
Children | 9 | 39.1 |
Adults | 7 | 30.4 |
Pregnant women | 4 | 17.4 |
All age groups | 1 | 4.34 |
Pregnant and nonpregnant women | 1 | 4.34 |
Not specified | 1 | 4.34 |
Clinical status | ||
Symptomatic malaria | 16 | 69.6 |
Asymptomatic malaria | 1 | 4.34 |
Status not defined | 6 | 26.1 |
Methods for malaria detection | ||
Microscopy | 22 | 95.7 |
Not specified | 1 | 4.30 |
Form of vitamin E | ||
α-tocopherol | 9 | 39.1 |
Total tocopherols | 2 | 8.70 |
Form was not specified | 12 | 52.2 |
Subgroup Analyses | p-Value | Cohen’s d (95% CI) | I2 (%) | Number of Studies |
---|---|---|---|---|
Continent | ||||
Africa | <0.01 | −3.10, −4.54–(−1.66) | 98.95 | 12 |
Asia | <0.01 | −1.74, −2.95–(−0.52) | 97.81 | 8 |
Age group | ||||
Children | <0.01 | −3.97, −5.35–(−2.59) | 98.76 | 9 |
Adults | <0.01 | −3.66, −5.07–(−2.25) | 94.41 | 6 |
Pregnant women | 0.43 | 0.88, −1.31–3.07 | 98.92 | 4 |
Children and adults | N/A | −0.89, −1.39–(−0.40) | N/A | 1 |
Not specified | N/A | −1.85, −2.48–(−1.22) | N/A | 1 |
Plasmodium species | ||||
P. falciparum | <0.01 | −2.79, −3.99–(−1.60) | 98.81 | 14 |
P. falciparum, P. vivax, P. Ovale | N/A | −8.02, −9.57–(−6.47) | N/A | 1 |
P. falciparum, P. vivax | <0.01 | −2.64, −4.32–(−0.95) | 96.88 | 4 |
Not specified | 0.93 | −0.16, −3.52–3.20 | 98.75 | 2 |
Forms of vitamin E | ||||
Total tocopherols | 0.30 | −13.66, −39.24–11.92 | 99.68 | 2 |
α-tocopherol | 0.08 | −0.69, −1.48–(−0.09) | 96.20 | 8 |
Not specified | <0.01 | −2.87, −4.81–(−0.93) | 99.01 | 11 |
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Kotepui, M.; Masangkay, F.R.; Mahittikorn, A.; Kotepui, K.U. Effect of Malaria on Blood Levels of Vitamin E: A Systematic Review and Meta-Analysis. Nutrients 2023, 15, 3472. https://doi.org/10.3390/nu15153472
Kotepui M, Masangkay FR, Mahittikorn A, Kotepui KU. Effect of Malaria on Blood Levels of Vitamin E: A Systematic Review and Meta-Analysis. Nutrients. 2023; 15(15):3472. https://doi.org/10.3390/nu15153472
Chicago/Turabian StyleKotepui, Manas, Frederick Ramirez Masangkay, Aongart Mahittikorn, and Kwuntida Uthaisar Kotepui. 2023. "Effect of Malaria on Blood Levels of Vitamin E: A Systematic Review and Meta-Analysis" Nutrients 15, no. 15: 3472. https://doi.org/10.3390/nu15153472
APA StyleKotepui, M., Masangkay, F. R., Mahittikorn, A., & Kotepui, K. U. (2023). Effect of Malaria on Blood Levels of Vitamin E: A Systematic Review and Meta-Analysis. Nutrients, 15(15), 3472. https://doi.org/10.3390/nu15153472