The Joint Effects of Bisphenols and Iodine Exposure on Thyroid during Pregnancy
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Population and Data Collection
2.2. Urine Collection and BPs Laboratory Measurements
2.3. Assessment of Iodine Nutrition Status
2.4. Thyroid Gland Function Assessment
2.5. EDI and Risk Assessment
2.6. Covariates
2.7. Statistical Analysis
3. Results
3.1. Characteristic of Study Populatio
3.2. Exposure Levels of Urinary BPA and Its Alternatives in Study Participants
3.3. Risk Assessment of Exposure to BPA and Its Alternatives
3.4. Overall Effects of BPs on Thyroid Health
3.5. Association between Each BPs and Thyroid Health
3.6. Interaction Effect between BPs and Iodine on Thyroid Antibodies
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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BPs | Percent Detection | Mean (95% CI) | Selected Percentiles | Geometric Mean (95% CI) | ||||
---|---|---|---|---|---|---|---|---|
10% | 25% | 50% | 75% | 90% | ||||
Unadjusted (ng/mL) | ||||||||
BPA | 90.36 | 2.35 (1.88, 2.82) | 0.63 | 0.81 | 1.30 | 2.08 | 3.65 | 1.44 (1.34, 1.53) |
BPB | 77.29 | 0.32 (0.26, 0.37) | 0.02 | 0.04 | 0.10 | 0.36 | 0.85 | 0.11 (0.10, 0.13) |
BPC | 86.00 | 2.08 (1.86, 2.29) | 0.34 | 0.62 | 1.24 | 2.42 | 4.86 | 1.27 (1.18, 1.39) |
BPF | 79.01 | 0.77 (0.62, 0.92) | 0.03 | 0.05 | 0.13 | 0.49 | 2.23 | 0.19 (0.16, 0.21) |
BPS | 84.76 | 0.31 (0.24, 0.39) | 0.04 | 0.06 | 0.11 | 0.26 | 0.65 | 0.14 (0.13, 0.15) |
BPAF | 79.94 | 0.28 (0.27, 0.29) | 0.20 | 0.22 | 0.26 | 0.33 | 0.40 | 0.27 (0.26, 0.28) |
ΣBPs | - | 5.29 (4.75, 5.83) | 1.15 | 1.94 | 3.56 | 6.37 | 10.78 | 3.41 (3.15, 3.68) |
Creatinine-adjusted (μg/g creatinine) | ||||||||
BPA | - | 8.20 (3.52, 12.88) | 0.99 | 1.52 | 2.64 | 5.19 | 10.42 | 3.03 (2.78, 3.30) |
BPB | - | 0.73 (0.50, 0.97) | 0.04 | 0.07 | 0.22 | 0.79 | 1.69 | 0.24 (0.21, 0.27) |
BPC | - | 6.52 (2.75, 10.28) | 0.74 | 1.24 | 2.67 | 5.06 | 10.08 | 2.66 (2.43, 2.92) |
BPF | - | 1.57 (1.18, 1.97) | 0.06 | 0.12 | 0.25 | 1.01 | 4.64 | 0.36 (0.31, 0.42) |
BPS | - | 0.76 (0.48, 1.04) | 0.06 | 0.11 | 0.24 | 0.55 | 1.32 | 0.26 (0.24, 0.29) |
BPAF | - | 1.52 (0.91, 2.12) | 0.22 | 0.37 | 0.61 | 1.25 | 2.72 | 0.72 (0.65, 0.78) |
ΣBPs | - | 16.72 (8.28, 25.17) | 2.53 | 4.14 | 7.88 | 14.37 | 25.17 | 7.55 (6.94, 8.21) |
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Lu, W.; Sun, Z.; Wang, Z.; Qu, M.; Shi, Z.; Song, Q.; Shen, L.; Mai, S.; Wang, Y.; Hong, X.; et al. The Joint Effects of Bisphenols and Iodine Exposure on Thyroid during Pregnancy. Nutrients 2023, 15, 3422. https://doi.org/10.3390/nu15153422
Lu W, Sun Z, Wang Z, Qu M, Shi Z, Song Q, Shen L, Mai S, Wang Y, Hong X, et al. The Joint Effects of Bisphenols and Iodine Exposure on Thyroid during Pregnancy. Nutrients. 2023; 15(15):3422. https://doi.org/10.3390/nu15153422
Chicago/Turabian StyleLu, Wei, Zhuo Sun, Zhengyuan Wang, Mengying Qu, Zehuan Shi, Qi Song, Liping Shen, Shupeng Mai, Yuan Wang, Xinyu Hong, and et al. 2023. "The Joint Effects of Bisphenols and Iodine Exposure on Thyroid during Pregnancy" Nutrients 15, no. 15: 3422. https://doi.org/10.3390/nu15153422