Next Article in Journal
Association of the Dietary Inflammatory Index with Depressive Symptoms among Pre- and Post-Menopausal Women: Findings from the National Health and Nutrition Examination Survey (NHANES) 2005–2010
Next Article in Special Issue
Weight Change across Adulthood in Relation to Non-Alcoholic Fatty Liver Disease among Non-Obese Individuals
Previous Article in Journal
Dried Ginger Extract Restores the T Helper Type 1/T Helper Type 2 Balance and Antibody Production in Cyclophosphamide-Induced Immunocompromised Mice after Flu Vaccination
Previous Article in Special Issue
Relationship between Serum 25-Hydroxyvitamin D Level and Risk of Recurrent Stroke
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Nutrients
Volume 14
Issue 9
10.3390/nu14091985
nutrients-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Nutraceuticals/Drugs Promoting Mitophagy and Mitochondrial Biogenesis May Combat the Mitochondrial Dysfunction Driving Progression of Dry Age-Related Macular Degeneration

by
Lidianys María Lewis Luján
1,
Mark F. McCarty
2,
James J. Di Nicolantonio
3,
Juan Carlos Gálvez Ruiz
4,
Ema Carina Rosas-Burgos
1,
Maribel Plascencia-Jatomea
1 and
Simon Bernard Iloki Assanga
4,*
1
Department of Research and Postgraduate in Food, University of Sonora, Blvd. Luis Encinas y Rosales S/N, Col. Centro, Hermosillo 83000, Mexico
2
Catalytic Longevity Foundation, San Diego, CA 92109, USA
3
St. Luke’s Mid America Heart Institute, Kansas City, MO 64111, USA
4
Department of Biological Chemical Sciences, Sonora University, Blvd. Luis Encinas y Rosales, Col. Centro, Hermosillo 83000, Mexico
*
Author to whom correspondence should be addressed.
Nutrients 2022, 14(9), 1985; https://doi.org/10.3390/nu14091985
Submission received: 27 March 2022 / Revised: 29 April 2022 / Accepted: 4 May 2022 / Published: 9 May 2022
(This article belongs to the Special Issue Nutritional Support for Chronic Disease)
Browse Figures
Review Reports Versions Notes

Abstract

In patients with age-related macular degeneration (AMD), the crucial retinal pigment epithelial (RPE) cells are characterized by mitochondria that are structurally and functionally defective. Moreover, deficient expression of the mRNA-editing enzyme Dicer is noted specifically in these cells. This Dicer deficit up-regulates expression of Alu RNA, which in turn damages mitochondria—inducing the loss of membrane potential, boosting oxidant generation, and causing mitochondrial DNA to translocate to the cytoplasmic region. The cytoplasmic mtDNA, in conjunction with induced oxidative stress, triggers a non-canonical pathway of NLRP3 inflammasome activation, leading to the production of interleukin-18 that acts in an autocrine manner to induce apoptotic death of RPE cells, thereby driving progression of dry AMD. It is proposed that measures which jointly up-regulate mitophagy and mitochondrial biogenesis (MB), by replacing damaged mitochondria with “healthy” new ones, may lessen the adverse impact of Alu RNA on RPE cells, enabling the prevention or control of dry AMD. An analysis of the molecular biology underlying mitophagy/MB and inflammasome activation suggests that nutraceuticals or drugs that can activate Sirt1, AMPK, Nrf2, and PPARα may be useful in this regard. These include ferulic acid, melatonin urolithin A and glucosamine (Sirt1), metformin and berberine (AMPK), lipoic acid and broccoli sprout extract (Nrf2), and fibrate drugs and astaxanthin (PPARα). Hence, nutraceutical regimens providing physiologically meaningful doses of several or all of the: ferulic acid, melatonin, glucosamine, berberine, lipoic acid, and astaxanthin, may have potential for control of dry AMD.
Keywords: nutraceuticals; age-related macular degeneration; mitochondrial biogenesis; Sirt1; AMPK; Nrf2; ferulic acid; melatonin; berberine; astaxanthin nutraceuticals; age-related macular degeneration; mitochondrial biogenesis; Sirt1; AMPK; Nrf2; ferulic acid; melatonin; berberine; astaxanthin

Share and Cite

MDPI and ACS Style

Lewis Luján, L.M.; McCarty, M.F.; Di Nicolantonio, J.J.; Gálvez Ruiz, J.C.; Rosas-Burgos, E.C.; Plascencia-Jatomea, M.; Iloki Assanga, S.B. Nutraceuticals/Drugs Promoting Mitophagy and Mitochondrial Biogenesis May Combat the Mitochondrial Dysfunction Driving Progression of Dry Age-Related Macular Degeneration. Nutrients 2022, 14, 1985. https://doi.org/10.3390/nu14091985

AMA Style

Lewis Luján LM, McCarty MF, Di Nicolantonio JJ, Gálvez Ruiz JC, Rosas-Burgos EC, Plascencia-Jatomea M, Iloki Assanga SB. Nutraceuticals/Drugs Promoting Mitophagy and Mitochondrial Biogenesis May Combat the Mitochondrial Dysfunction Driving Progression of Dry Age-Related Macular Degeneration. Nutrients. 2022; 14(9):1985. https://doi.org/10.3390/nu14091985

Chicago/Turabian Style

Lewis Luján, Lidianys María, Mark F. McCarty, James J. Di Nicolantonio, Juan Carlos Gálvez Ruiz, Ema Carina Rosas-Burgos, Maribel Plascencia-Jatomea, and Simon Bernard Iloki Assanga. 2022. "Nutraceuticals/Drugs Promoting Mitophagy and Mitochondrial Biogenesis May Combat the Mitochondrial Dysfunction Driving Progression of Dry Age-Related Macular Degeneration" Nutrients 14, no. 9: 1985. https://doi.org/10.3390/nu14091985

APA Style

Lewis Luján, L. M., McCarty, M. F., Di Nicolantonio, J. J., Gálvez Ruiz, J. C., Rosas-Burgos, E. C., Plascencia-Jatomea, M., & Iloki Assanga, S. B. (2022). Nutraceuticals/Drugs Promoting Mitophagy and Mitochondrial Biogenesis May Combat the Mitochondrial Dysfunction Driving Progression of Dry Age-Related Macular Degeneration. Nutrients, 14(9), 1985. https://doi.org/10.3390/nu14091985

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop