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Review

Pomegranate (Punica granatum L.) and Metabolic Syndrome Risk Factors and Outcomes: A Systematic Review of Clinical Studies

1
Department of Biochemistry and Pharmacology, School of Medicine, University of Marília, Marília 17525-902, SP, Brazil
2
Postgraduate Program in Structural and Functional Interactions in Rehabilitation, University of Marília, Marília 17525-902, SP, Brazil
3
Department of Biochemistry, School of Food and Technology of Marilia, Marília 17500-000, SP, Brazil
4
College of Osteopathic Medicine, Lake Erie College of Osteopathic Medicine, Bradenton, FL 34211, USA
*
Authors to whom correspondence should be addressed.
Academic Editors: Jean Christopher Chamcheu, Anthony L. Walker and Felicite Noubissi-Kamdem
Nutrients 2022, 14(8), 1665; https://doi.org/10.3390/nu14081665
Received: 29 March 2022 / Revised: 12 April 2022 / Accepted: 14 April 2022 / Published: 16 April 2022
Pomegranate (Punica granatum L.) can be considered a multipurpose medicinal and dietary plant due to its anti-inflammatory and antioxidant actions. Pomegranate can be used to prevent or treat metabolic syndrome (MetS) risk factors. Although previously published reviews addressed the effects of pomegranate on different diseases, there is no systematic review that exclusively focuses on clinical trials related to all MetS-related risk factors. In view of this limitation, the objective of this up-to-date, comprehensive, and systematic review is to critically evaluate the potential of pomegranate (P. granatum) on various MetS risk factors on the basis of clinical studies. PubMed, EMBASE, MEDLINE, Google Scholar, COCHRANE, and Clinical Trials.gov databases were searched on 15 October 2021. The Preferred Reporting Items for a Systematic Review and Meta-Analysis guidelines were followed, and the bias risk evaluation was performed according to the Cochrane Handbook for Systematic Reviews of Interventions. We identified 5683 studies in the databases. After removing the duplicates, 3418 studies remained. Of these, 147 studies met the eligibility criteria, and finally, only 20 were included in the qualitative analysis. The included studies suggest that pomegranate can be beneficial to reduce body weight, blood pressure, glycemia, triglycerides, total cholesterol, and low-density lipoprotein cholesterol. Moreover, it can augment high-density lipoprotein cholesterol levels and improve insulin resistance. Although relevant effects were observed, additional well-designed clinical trials are needed to determine the correct formulations and doses to be used to prevent or treat MetS components. View Full-Text
Keywords: Punica granatum; pomegranate; body weight; hyperglycemia; hypertension; metabolic syndrome Punica granatum; pomegranate; body weight; hyperglycemia; hypertension; metabolic syndrome
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MDPI and ACS Style

Laurindo, L.F.; Barbalho, S.M.; Marquess, A.R.; Grecco, A.I.d.S.; Goulart, R.d.A.; Tofano, R.J.; Bishayee, A. Pomegranate (Punica granatum L.) and Metabolic Syndrome Risk Factors and Outcomes: A Systematic Review of Clinical Studies. Nutrients 2022, 14, 1665. https://doi.org/10.3390/nu14081665

AMA Style

Laurindo LF, Barbalho SM, Marquess AR, Grecco AIdS, Goulart RdA, Tofano RJ, Bishayee A. Pomegranate (Punica granatum L.) and Metabolic Syndrome Risk Factors and Outcomes: A Systematic Review of Clinical Studies. Nutrients. 2022; 14(8):1665. https://doi.org/10.3390/nu14081665

Chicago/Turabian Style

Laurindo, Lucas F., Sandra M. Barbalho, Alexis R. Marquess, Annik I.d.S. Grecco, Ricardo d.A. Goulart, Ricardo J. Tofano, and Anupam Bishayee. 2022. "Pomegranate (Punica granatum L.) and Metabolic Syndrome Risk Factors and Outcomes: A Systematic Review of Clinical Studies" Nutrients 14, no. 8: 1665. https://doi.org/10.3390/nu14081665

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