Neuroprotective Effect of 1,3-dipalmitoyl-2-oleoylglycerol Derived from Rice Bran Oil against Cerebral Ischemia-Reperfusion Injury in Rats

Round 1

Reviewer 1 Report

This study is one of the novel study which investigate the neuroprotective effect of 1,3-dipalmitoyl-2-oleoylglycerol derived from rice bran oil against cerebral ischemia-reperfusion injury in rats. It provides a valuable data about the effect of 1,3-dipalmitoyl-2-oleoylglycerol as anti-oxidant, anti-apoptotic, and anti-inflammatory action.

Also, this study exhibited that the POP might be effectively applied for the management of cerebral ischemic injury-related diseases.

• This study answered the research question clearly.
• Authors have to acknowledge the support from the institutions or research centers that effectively support and provide a facility for doing this research.
• References should be standardized according to the instruction of the journal. full stop should be added for the abbreviated journal names.
• Some tying errors are there, it needs correction.

Author Response

• Response to reviewer 1
• Authors have to acknowledge the support from the institutions or research centers that effectively support and provide a facility for doing this research.

 answer; We added it.

• References should be standardized according to the instruction of the journal. full stop should be added for the abbreviated journal names.

 answer; We modified it.

• Some typing errors are there, it needs correction.

 answer; We modified it.

Author Response File: Author Response.docx

Reviewer 2 Report

The Authors focused on a study of the Neuroprotective Effect of 1,3-dipalmitoyl-2-oleoylglycerol Derived from Rice Bran Oil Against Cerebral Ischemia-Reperfusion Injury in Rats. This is an interesting and comprehensive study. The article is well structured.

In my opinion:

-                The abstract presents an accurate description of this review.

-                An Authors was conducted adequate literature review.

-                The references support the rationale for reporting the study.

-                The subjects are described adequately.

-                The management of the study is effectively described.

-                Valid and reliable outcome measures are utilized.

-                The management of the manuscript is effectively described.

-                The conclusions are appropriate.

Overall impression about the quality of the study is good.

Line 12 – “1, 3-dipalmitoyl-2-oleoylglycerol”, please fix it to “1,3-dipalmitoyl-2-oleoylglycerol”

Line 12 – triacylglyceride, please add abbreviation to name (first time in the manuscript)

Line 29 – “1; 3-dipalmitoyl-2-oleoylglycerol”, please fix it to “1,3-dipalmitoyl-2-oleoylglycerol”

Line 61 – Triacylglyceride (TAG) - it is not necessary to explain the abbreviations, it was before, use just shorts

Line 85, 86 – different font, please fix it

Author Response

Response to Reviewer 2

Line 12 – “1, 3-dipalmitoyl-2-oleoylglycerol”, please fix it to “1,3-dipalmitoyl-2-oleoylglycerol”

 answer; We modified it.

Line 12 – triacylglyceride, please add abbreviation to name (first time in the manuscript)

 answer; Since triacylglyceride appears only once in abstract, it is considered unnecessary to use the abbreviation in abstract.

Line 29 – “1; 3-dipalmitoyl-2-oleoylglycerol”, please fix it to “1,3-dipalmitoyl-2-oleoylglycerol”

 answer; We modified it.

Line 61 – Triacylglyceride (TAG) - it is not necessary to explain the abbreviations, it was before, use just shorts

 answer; Since Triacylglyceride (TAG) appears for the first time in the main text, an abbreviation is indicated.

Line 85, 86 – different font, please fix it

 answer; We modified it.

Author Response File: Author Response.docx