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Article

Searching for a Longevity Food, We Bump into Hericium erinaceus Primordium Rich in Ergothioneine: The “Longevity Vitamin” Improves Locomotor Performances during Aging

1
Laboratory of Clinical & Experimental Toxicology, Pavia Poison Centre, National Toxicology Information Centre, Toxicology Unit, Istituti Clinici Scientifici Maugeri IRCCS, 27100 Pavia, Italy
2
Department of Biology and Biotechnology “L. Spallanzani”, University of Pavia, 27100 Pavia, Italy
3
Department of Earth and Environmental Sciences, University of Pavia, 27100 Pavia, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Stephane V. Sizonenko
Nutrients 2022, 14(6), 1177; https://doi.org/10.3390/nu14061177
Received: 19 January 2022 / Revised: 2 March 2022 / Accepted: 8 March 2022 / Published: 11 March 2022
(This article belongs to the Collection Nutrition for Brain Development and Repair)
Phenotypic frailty is characterized by a progressive decline in physical functioning. During ageing, morphological and functional alterations involve the brain, and chief theories involve oxidative stress, free radical accumulation, and reduced antioxidant defenses as the most implicated mechanisms. From boosting the immune system to fighting senescence, medicinal mushrooms have been found to have a number of health and longevity benefits. Among them, Hericium erinaceus (He) has been demonstrated to display a variety of physiological effects, including anti-aging properties. Thus, He represents an attractive natural source for developing novel medicines and functional foods, based on the identification of its active ingredients and metabolites. Particularly, H. erinaceus primordium (He2) extract contains a high amount of Ergothioneine (ERGO), the longevity vitamin. Herein, we revealed the preventive effect of ERGO-rich He2 extract in a preclinical model, focusing on locomotor decline during ageing monitored through spontaneous behavioral test. This effect was accompanied by a significant decrease in some oxidative stress markers (NOS2, COX2) paralleled by an increase in P53, showed in cerebellar cortex cells and fibres by immunohistochemistry. In summary, we demonstrated the neuro-protective and preventive effects of He2 extract during aging, probably due to its peculiarly high ERGO content. View Full-Text
Keywords: frailty; medicinal mushroom supplementation; Hericium erinaceus; primordium; oxidative stress; frail prevention; neuroprotection frailty; medicinal mushroom supplementation; Hericium erinaceus; primordium; oxidative stress; frail prevention; neuroprotection
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MDPI and ACS Style

Roda, E.; Ratto, D.; De Luca, F.; Desiderio, A.; Ramieri, M.; Goppa, L.; Savino, E.; Bottone, M.G.; Locatelli, C.A.; Rossi, P. Searching for a Longevity Food, We Bump into Hericium erinaceus Primordium Rich in Ergothioneine: The “Longevity Vitamin” Improves Locomotor Performances during Aging. Nutrients 2022, 14, 1177. https://doi.org/10.3390/nu14061177

AMA Style

Roda E, Ratto D, De Luca F, Desiderio A, Ramieri M, Goppa L, Savino E, Bottone MG, Locatelli CA, Rossi P. Searching for a Longevity Food, We Bump into Hericium erinaceus Primordium Rich in Ergothioneine: The “Longevity Vitamin” Improves Locomotor Performances during Aging. Nutrients. 2022; 14(6):1177. https://doi.org/10.3390/nu14061177

Chicago/Turabian Style

Roda, Elisa, Daniela Ratto, Fabrizio De Luca, Anthea Desiderio, Martino Ramieri, Lorenzo Goppa, Elena Savino, Maria Grazia Bottone, Carlo Alessandro Locatelli, and Paola Rossi. 2022. "Searching for a Longevity Food, We Bump into Hericium erinaceus Primordium Rich in Ergothioneine: The “Longevity Vitamin” Improves Locomotor Performances during Aging" Nutrients 14, no. 6: 1177. https://doi.org/10.3390/nu14061177

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