Meta-Analysis of Randomized Clinical Trials Evaluating Effectiveness of a Multivitamin Supplementation against Oxidative Stress in Healthy Subjects
, Iksoo Huh 2,†, Seunghee Kang 3, Yea-eun Nam 3, Youngseo Cho 4, Md Kamruzzaman 4, Jina Hong 5, Oran Kwon 3,* and Taesung Park 4,*Round 1
Reviewer 1 Report
The authors of the article entitled “Meta-Analysis of Randomized Clinical Trials Evaluating Effectiveness of a Multivitamin Supplementation against Oxidative Stress in Healthy Subjects” applied a meta-analysis to 6 randomized placebo-controlled trials to investigate the relationship between plant-based multivitamin/mineral supplementation and oxidative stress.
Please, revise the affiliations (the 5 does not appear) and superscripts (*, and †).
Lines 80, 211, and 283. The symbol is not a ‘beta’.
Table 2. Why ‘α-tocopherol’ was in boldface and underlined?
Table 3, and 4. Why ‘Vitamin C’ was in boldface and underlined?
Figure 1C. Can you trust this result? The r-value is very poor, and the statistical significance can be due to the folate value > 5.0 (one point). It is not an outlier?
Author Response
We thank you for your helpful and positive comments. Please see the attachment file for detailed responses to your comments.
Author Response File: 
Author Response.docx
Reviewer 2 Report
- the study is well conducted and designed
- the meta-analysis supports a general benefit of PMS in alleviating oxidative stress by providing free radical scavenging nutrients in the general population with a habitually low intake of fruit and vegetables
- the authors identify the strong points and also the weak ones of the study
Author Response
We thank you very much for your positive comments. We appreciate it.
