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Article

Meta-Analysis of Randomized Clinical Trials Evaluating Effectiveness of a Multivitamin Supplementation against Oxidative Stress in Healthy Subjects

1
College of Liberal Studies, Department of Liberal Studies, Seoul National University, Seoul 08826, Korea
2
College of Nursing, Research Institute of Nursing Science, Seoul National University, Seoul 03080, Korea
3
Graduate Program in System Health Science and Engineering, Department of Nutritional Science and Food Management, Ewha Womans University, Seoul 03760, Korea
4
Department of Statistics, Seoul National University, Seoul 08826, Korea
5
Access Business Group International, LLC, 5600 Beach Blvd., Buena Park, CA 90621, USA
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Wojciech Kolanowski and Anna Gramza-Michałowska
Nutrients 2022, 14(6), 1170; https://doi.org/10.3390/nu14061170
Received: 11 February 2022 / Revised: 4 March 2022 / Accepted: 7 March 2022 / Published: 10 March 2022
(This article belongs to the Topic Applied Sciences in Functional Foods)
A meta-analysis has been widely applied to draw general conclusions using a set of studies with similar purposes and designs. This study aimed to perform a meta-analysis of six randomized placebo-controlled trials, independently conducted for the relationship between a plant-based multivitamin/mineral supplementation (PMS) and oxidative stress for 6 to 8 weeks, to provide overall estimates of those effects. In detail, linear mixed model analysis was first conducted on each study to obtain individual estimates; then, two types of meta-analysis were applied to combine the individual estimates from all available studies (overall meta-analysis) and region-specific studies (subgroup meta-analysis). In the meta-analysis, we selected 19 biomarker variables that overlapped in at least two studies and found 6 variables significant in at least one meta-analysis. The overall estimates of beta coefficients were 0.17 for vitamin C, 0.80 for vitamin B6, 0.46 for vitamin B12, 0.81 for folate, 0.36 for β-carotene, and −0.17 for oxidized LDL (ox-LDL). Subsequent association analysis revealed significant negative correlations between plasma free radical scavenging nutrients and plasma ox-LDL levels, indicating a general benefit of PMS in alleviating oxidative stress by providing exogenous oxidant scavengers. View Full-Text
Keywords: meta-analysis; multivitamin supplementation; exogenous oxidant scavenger; oxidative damage meta-analysis; multivitamin supplementation; exogenous oxidant scavenger; oxidative damage
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MDPI and ACS Style

Lee, S.; Huh, I.; Kang, S.; Nam, Y.-e.; Cho, Y.; Kamruzzaman, M.; Hong, J.; Kwon, O.; Park, T. Meta-Analysis of Randomized Clinical Trials Evaluating Effectiveness of a Multivitamin Supplementation against Oxidative Stress in Healthy Subjects. Nutrients 2022, 14, 1170. https://doi.org/10.3390/nu14061170

AMA Style

Lee S, Huh I, Kang S, Nam Y-e, Cho Y, Kamruzzaman M, Hong J, Kwon O, Park T. Meta-Analysis of Randomized Clinical Trials Evaluating Effectiveness of a Multivitamin Supplementation against Oxidative Stress in Healthy Subjects. Nutrients. 2022; 14(6):1170. https://doi.org/10.3390/nu14061170

Chicago/Turabian Style

Lee, Seoyoung, Iksoo Huh, Seunghee Kang, Yea-eun Nam, Youngseo Cho, Md Kamruzzaman, Jina Hong, Oran Kwon, and Taesung Park. 2022. "Meta-Analysis of Randomized Clinical Trials Evaluating Effectiveness of a Multivitamin Supplementation against Oxidative Stress in Healthy Subjects" Nutrients 14, no. 6: 1170. https://doi.org/10.3390/nu14061170

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