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Antidiabetic Effects of Pediococcus acidilactici pA1c on HFD-Induced Mice

1
Biochemistry Area, Department of Health Science, Public University of Navarre, 31008 Pamplona, Spain
2
Genbioma Aplicaciones SL., 31191 Esquíroz, Spain
3
IDISNA Navarra’s Health Research Institute, 31008 Pamplona, Spain
4
Division of Hematological-Oncology, CIMA, University of Navarre, 31006 Pamplona, Spain
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Lindsay Brown
Nutrients 2022, 14(3), 692; https://doi.org/10.3390/nu14030692
Received: 22 December 2021 / Revised: 28 January 2022 / Accepted: 28 January 2022 / Published: 7 February 2022
(This article belongs to the Topic Probiotics, Prebiotics and Postbiotics in Human Health)
Prediabetes (PreD), which is associated with impaired glucose tolerance and fasting blood glucose, is a potential risk factor for type 2 diabetes mellitus (T2D). Growing evidence suggests the role of the gastrointestinal microbiota in both PreD and T2D, which opens the possibility for a novel nutritional approach, based on probiotics, for improving glucose regulation and delaying disease progression of PreD to T2D. In this light, the present study aimed to assess the antidiabetic properties of Pediococcus acidilactici (pA1c) in a murine model of high-fat diet (HFD)-induced T2D. For that purpose, C57BL/6 mice were given HFD enriched with either probiotic (1 × 1010 CFU/day) or placebo for 12 weeks. We determined body weight, fasting blood glucose, glucose tolerance, HOMA-IR and HOMA-β index, C-peptide, GLP-1, leptin, and lipid profile. We also measured hepatic gene expression (G6P, PEPCK, GCK, IL-1β, and IL-6) and examined pancreatic and intestinal histology (% of GLP-1+ cells, % of goblet cells and villus length). We found that pA1c supplementation significantly attenuated body weight gain, mitigated glucose dysregulation by reducing fasting blood glucose levels, glucose tolerance test, leptin levels, and insulin resistance, increased C-peptide and GLP-1 levels, enhanced pancreatic function, and improved intestinal histology. These findings indicate that pA1c improved HFD-induced T2D derived insulin resistance and intestinal histology, as well as protected from body weight increase. Together, our study proposes that pA1c may be a promising new dietary management strategy to improve metabolic disorders in PreD and T2D. View Full-Text
Keywords: Pediococcus acidilactici; fasting blood glucose; insulin sensitivity; prediabetes; diabetes; high-fat diet; probiotics; gut microbiota and dysbiosis Pediococcus acidilactici; fasting blood glucose; insulin sensitivity; prediabetes; diabetes; high-fat diet; probiotics; gut microbiota and dysbiosis
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MDPI and ACS Style

Cabello-Olmo, M.; Oneca, M.; Pajares, M.J.; Jiménez, M.; Ayo, J.; Encío, I.J.; Barajas, M.; Araña, M. Antidiabetic Effects of Pediococcus acidilactici pA1c on HFD-Induced Mice. Nutrients 2022, 14, 692. https://doi.org/10.3390/nu14030692

AMA Style

Cabello-Olmo M, Oneca M, Pajares MJ, Jiménez M, Ayo J, Encío IJ, Barajas M, Araña M. Antidiabetic Effects of Pediococcus acidilactici pA1c on HFD-Induced Mice. Nutrients. 2022; 14(3):692. https://doi.org/10.3390/nu14030692

Chicago/Turabian Style

Cabello-Olmo, Miriam, María Oneca, María José Pajares, Maddalen Jiménez, Josune Ayo, Ignacio J. Encío, Miguel Barajas, and Miriam Araña. 2022. "Antidiabetic Effects of Pediococcus acidilactici pA1c on HFD-Induced Mice" Nutrients 14, no. 3: 692. https://doi.org/10.3390/nu14030692

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